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Recent Patents of Interest in Proteomics: Sep 21, 2006

US Patent 7,105,339. Retentate chromatography and protein chip arrays with application in biology and medicine. Inventors: T. William Hutchens; Tai-Tung Yip. Assignee: Ciphergen Biosystems
Inventors discovered methods of retentate chromatography for resolving analytes in a sample involving “adsorbing the analytes to a substrate under a plurality of different selectivity conditions and detecting the analytes retained on the substrate by desorption spectrometry,” according to the patent’s abstract.

US Patent No. 7,102,005. Composition and methods for detection and isolation of phosphorylated molecules. Inventors: Brian Agnew; Joseph Beechem; Kyle Gee; Richard Haugland; Jixiang Liu; Vladimir Martin; Wayne Patton, and Thomas Steinberg. Assignee: Molecular Probes
The invention relates to phosphate-binding compounds used for binding, detecting, and isolating phosphorylated target molecules. The binding solution of the invention can be used for binding and detecting immobilized and solubilized phosphorylated target molecules “and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified,” said the inventors in the patent’s abstract.

US Patent 7,101,968. One-step reduction and alkylation of proteins. Inventors: John Hale and Michael Knierman. Assignee: Indiana Proteomics Consortium
The invention disclosed a novel composition and method for reducing and alkylating proteins. “A novel reagent including a combination of a volatile reducing agent, a volatile alkylating agent, and a volatile solvent is used for a one-step reduction and alkylation of proteins allowing the protein sample to remain in the same container during the reduction and alkylation processes,” the inventors said in the patent’s abstract.

US Patent 7,091,046. Multiplexed protein expression and activity assay. Inventors: Joseph Monforte. Assignee: HK Pharmaceuticals.
The invention relates to a system for analyzing expression levels and activity of a plurality of proteins. Proteins are bound by a bio-displayed polypeptide binding component associated with a predetermined marker. The marker components are then amplified and detected in a high-throughput manner.

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Machine Learning Improves Diagnostic Accuracy of Breast Cancer MRI, Study Shows

Combining machine learning with radiologists' interpretations further increased the diagnostic accuracy of MRIs for breast cancer, a Science Translational Medicine paper finds.

Genome Damage in Neurons Triggers Alzheimer's-Linked Inflammation

Neurons harboring increased DNA double-strand breaks activate microglia to lead to neuroinflammation like that seen in Alzheimer's disease, a new Science Advances study finds.

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.