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Recent Patents of Interest in Proteomics: Aug 24, 2006

US Patent No. 7,090,333. Focused acoustic energy in the preparation of peptide arrays. Inventors: Mitchell Mutz and Richard Ellson. Assignee: Picoliter
The invention relates to arrays of peptidic molecules and the preparation of peptide arrays. The arrays are prepared using focused acoustic energy. Peptide-containing fluid droplets are ejected from individual reservoirs toward designated sites on a substrate for attachment.

US Patent No. 7,085,765. Methods to increase the capacity of high content cell-based screening assays. Inventors: Joseph Zock, and Megan Weiss. Assignee: Cellomics
The invention pertains to the pooling of multiple high-content cell-based screening assays. A primary screen is carried out in one or more channels of a fluorescence detection device, “drastically [increasing] the number of simultaneous high content cell-based screening events that can be carried out,” according to the abstract.

US Patent No. 7,081,954. Micoarray detector and synthesizer. Inventor: Perry Sandstrom. Assignee: Able Signal Company
The invention relates to novel systems, devices, and methods used to read and synthesize microarrays. The invention uses spatial modulators for such purpose.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.