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Recent Patents of Interest in Proteomics: Oct 19, 2006

US Patent 7,122,377. Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures. Inventors: Yongchang Qui; Jack Wang; Rodney Hewick. Assignee: Genetics Institute
The patent covers a method for quantitative mass spectrometric analysis of protein mixtures. In combination with the inventors’ novel dual column 2D LC-MS/MS design, the method “proves to a general approach for quantitative mass spectrometric analysis of protein mixtures with better dynamic range and sensitivity,” according to the patent’s abstract.  

US Patent No. 7,117,096. Structure-based selection and affinity maturation of antibody library. Inventors: Peizhi Luo; Mark Hsieh; Pingyu Zhong; Caili Wang. Assignee: Abmaxis.
The invention provides a structure-based methodology for generating and screening protein libraries for optimized proteins with desirable biological functions.

US Patent No. 7,115,371. Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders. Inventors: James Eberwine. Assignee: Trustees of the University of Pennsylvania.
“Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen-bound complexes of immunogen-binding agent attached to a DNA containing an RNA polymerase promoter,” the authors say in their abstract.

US Patent 7,112,453. Retentate chromatography and protein chip arrays with application in biology and medicine. Inventors: William Hutchens, and Tai-Tung Yip. Assignee: Ciphergen Biosystems.
The inventions provides methods of retentate chromatography for resolving analytes in a sample and involves adsorbing the analytes to a substrate under a plurality of different selectivity conditions, then detecting the analytes retained on the substrate by desorption spectrometry.

US Patent 7,112,446. Method for analyzing protein or peptide. Inventors: Hirotaka Minagawa; Ichiro Ishida; Akira Tsugita; Takuji Nabetani. Assignee: Tokyo Rikakikai, and NEC
The invention pertains to a method for analyzing a posttranslational modification of a protein using no enzyme. A protein or peptide to be analyzed is reacted with an acid, making it possible to detect variously modified states of a protein or peptide.

US Patent 7,109,040. Modular isotope coding approach to proteomic analysis. Inventors: James Apffel Jr., and Karla Robotti. Assignee: Agilent Technologies.
The invention pertains to methods for analyzing peptides of interest in protein samples using a combination of relatively generic isotope tags with a decoupled selection process.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.