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Recent Patents of Interest in Proteomics: Oct 19, 2006

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US Patent 7,122,377. Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures. Inventors: Yongchang Qui; Jack Wang; Rodney Hewick. Assignee: Genetics Institute
 
The patent covers a method for quantitative mass spectrometric analysis of protein mixtures. In combination with the inventors’ novel dual column 2D LC-MS/MS design, the method “proves to a general approach for quantitative mass spectrometric analysis of protein mixtures with better dynamic range and sensitivity,” according to the patent’s abstract.  
 

 
US Patent No. 7,117,096. Structure-based selection and affinity maturation of antibody library. Inventors: Peizhi Luo; Mark Hsieh; Pingyu Zhong; Caili Wang. Assignee: Abmaxis.
 
The invention provides a structure-based methodology for generating and screening protein libraries for optimized proteins with desirable biological functions.
 

 
US Patent No. 7,115,371. Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders. Inventors: James Eberwine. Assignee: Trustees of the University of Pennsylvania.
 
“Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen-bound complexes of immunogen-binding agent attached to a DNA containing an RNA polymerase promoter,” the authors say in their abstract.
 

 
US Patent 7,112,453. Retentate chromatography and protein chip arrays with application in biology and medicine. Inventors: William Hutchens, and Tai-Tung Yip. Assignee: Ciphergen Biosystems.
 
The inventions provides methods of retentate chromatography for resolving analytes in a sample and involves adsorbing the analytes to a substrate under a plurality of different selectivity conditions, then detecting the analytes retained on the substrate by desorption spectrometry.
 

 
US Patent 7,112,446. Method for analyzing protein or peptide. Inventors: Hirotaka Minagawa; Ichiro Ishida; Akira Tsugita; Takuji Nabetani. Assignee: Tokyo Rikakikai, and NEC
 
The invention pertains to a method for analyzing a posttranslational modification of a protein using no enzyme. A protein or peptide to be analyzed is reacted with an acid, making it possible to detect variously modified states of a protein or peptide.
 

 
US Patent 7,109,040. Modular isotope coding approach to proteomic analysis. Inventors: James Apffel Jr., and Karla Robotti. Assignee: Agilent Technologies.
 
The invention pertains to methods for analyzing peptides of interest in protein samples using a combination of relatively generic isotope tags with a decoupled selection process.

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