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Recent Patents of Interest in Proteomics: Jan 4, 2007

US Patent 7,158,903. Methods for quantitative analysis by tandem mass spectrometry. Inventors: Mark Kushnir; Alan Rockwood; Gordon Nelson. Assignee: University of Utah.
The invention pertains to methods for high throughput analysis of analytes in complex mixtures for unresolved chromatographic peaks.

US Patent 7,158,862. Method and system for mining mass spectral data. Inventors: Daniel Liebler; Beau Hansen; Daniel Mason; Sean Davey; Juliet Jones; Thomas McClure. Assignee: The Arizona Board of Regents on behalf of the University of Arizona.
Invention pertains to a method, system, and a computer program product for mining mass spectral data for the detection of chemic-specific characteristic features in large databases and/or files “including specifying spectral characteristics of mass spectra to mine, specifying a relationship between the spectral characteristics, searching the mass spectra for portions of the mass spectra which match the spectral characteristics based on the relationship, and assigning scores to the portions of mass spectra to indicate a degree of correlation between the portions of mass spectra and the spectral characteristics,” according the patent abstract.

US Patent 7,157,557. Increased recovery of active proteins. Inventors: Helmut Sassenfel; Richard Remmele; Rebecca McCoy. Assignee: Immunex.
Invention pertains to methods of increasing yields of desired conformation of proteins. In some embodiments, the invention includes “contacting preparations of a recombinant protein with a reduction/oxidation coupling reagent for a time sufficient to increase the relative proportion of a desired configurational isomer.”

US Patent 7,150,973. Methods and kits for purifying his-tagged proteins. Inventors: Tonny Johnson, Rebecca Godat, Laurie Engel. Assignee: Promega.
Invention pertains to methods for separating a target molecule from a non-target one using zinc- or cobalt-charged solid supports.

US Patent 7,148,071. Quantitative, high-throughput screening method for protein stability. Inventors: Terence Oas; Sina Ghaemmaghami; Kendall Powell; Michael Fitzgerald. Assignee: Duke University.
Invention pertains to methods for measuring the stability of proteins in a rapid, high throughput manner. By use of MALDI, the methods employs hydrogen exchange to determine the stability of quantities of unpurified protein extracts.

US Patent 7,148,334. Composition for protecting proteins degradation comprising small heat shock proteins (sHSPs) and method of two-dimensional gel electrophoresis using the sHSPs. Inventors: Sang Yup Lee; Mee-Jung Han; Si Jae Park. Assignee: Korea Advanced Institute of Science and Technology.
The invention pertains to a composition containing sHSPs for the prevention of protein degradation and a composition for 2D gel electrophoresis. Inventors also say that the invention improves 2D gel electrophoresis by using sHSPs for characterization. Decreasing of protein spots was prevented in the 2D gel electrophoresis, resulting in more protein spots being obtained, the inventors say.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.