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Recent Patents of Interest in Proteomics: Feb 15, 2007

US Patent 7,176,287. Methods of detecting interactions between proteins, peptides, or libraries thereof using fusion proteins. Inventors: Andrew Hamilton; Indraneel Ghosh; Lynne Regan. Assignee: Yale University.
Invention pertains to a method of identification of a polypeptide that interacts with a known protein. The method uses proteins with GFP fragments.

US Patent 7,176,035. Protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction.Inventor: Elias George. Assignee: Elias George.
Inventors used overlapping hexapeptides that encode for the entire amino acid sequences of the linker domains of human P-glycoprotein gene 1 and 3. By doing so, they demonstrated a direct and specific binding between HP-gp1 and 3 linker domains and intracellular proteins, they said in the abstract.

US Patent 7,175,986. Methods and reagents for differential proteomic analysis. Inventors: Nathaniel Tran. Assignee: Proteomyx
Invention pertains to methods and reagents for labeling molecules of interest in multiple samples, then combining and selecting labeled molecules away from unlabeled molecules for use in simultaneous co-assaying analysis.

US Patent 7,172,739. Protein Fractionation. Inventors: David Maughan. Assignee: University of Vermont and State Agricultural College.
Patent pertains to a method and apparatus for separating polypeptide constituents of a sample fluid. A sample fluid made up of a mixture of polypeptides with different physical and/or chemical properties are contacted with at least two individual polymer matrix units. Each polymer matrix unit accepts a different set of polypeptides based on physical and/or chemical properties of the polypeptides. Finally, the polypeptides are extracted from each polymer matrix unit.

US Patent 7,170,599. Method and instrument for detecting biomolecular interactions. Inventors: Brian Cunningham; Peter Li. Assignee: SRU Biosystems.
Patent pertains to a method and apparatus for the detection of biomolecular interactions. The system includes an array of detection locations and comprises a light source for generating collimated white light. The use of labels is not required and the methods may be performed in a high-throughput manner, according to the abstract.

US Patent 7,169,617. Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules. Inventors: Kenji Arinaga; Ulrich Rant. Assignee: Fujitsu
Patent pertains to a device equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte. Technologies are also provided, including one for controlling the density of molecules attached to the surface of a solid.

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