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Recent Patents of Interest in Proteomics: Feb 15, 2007

US Patent 7,176,287. Methods of detecting interactions between proteins, peptides, or libraries thereof using fusion proteins. Inventors: Andrew Hamilton; Indraneel Ghosh; Lynne Regan. Assignee: Yale University.
Invention pertains to a method of identification of a polypeptide that interacts with a known protein. The method uses proteins with GFP fragments.

US Patent 7,176,035. Protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction.Inventor: Elias George. Assignee: Elias George.
Inventors used overlapping hexapeptides that encode for the entire amino acid sequences of the linker domains of human P-glycoprotein gene 1 and 3. By doing so, they demonstrated a direct and specific binding between HP-gp1 and 3 linker domains and intracellular proteins, they said in the abstract.

US Patent 7,175,986. Methods and reagents for differential proteomic analysis. Inventors: Nathaniel Tran. Assignee: Proteomyx
Invention pertains to methods and reagents for labeling molecules of interest in multiple samples, then combining and selecting labeled molecules away from unlabeled molecules for use in simultaneous co-assaying analysis.

US Patent 7,172,739. Protein Fractionation. Inventors: David Maughan. Assignee: University of Vermont and State Agricultural College.
Patent pertains to a method and apparatus for separating polypeptide constituents of a sample fluid. A sample fluid made up of a mixture of polypeptides with different physical and/or chemical properties are contacted with at least two individual polymer matrix units. Each polymer matrix unit accepts a different set of polypeptides based on physical and/or chemical properties of the polypeptides. Finally, the polypeptides are extracted from each polymer matrix unit.

US Patent 7,170,599. Method and instrument for detecting biomolecular interactions. Inventors: Brian Cunningham; Peter Li. Assignee: SRU Biosystems.
Patent pertains to a method and apparatus for the detection of biomolecular interactions. The system includes an array of detection locations and comprises a light source for generating collimated white light. The use of labels is not required and the methods may be performed in a high-throughput manner, according to the abstract.

US Patent 7,169,617. Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules. Inventors: Kenji Arinaga; Ulrich Rant. Assignee: Fujitsu
Patent pertains to a device equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte. Technologies are also provided, including one for controlling the density of molecules attached to the surface of a solid.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.