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Recent Patents of Interest in Proteomics : Mar 8, 2007

US Patent 7,188,034. Method and device for monitoring an analyte concentration in the living body of a human or animal. Inventors: Arnulf Staib; Rainer Hegger. Assignee: Roche Diagnostics Operations.
Invention pertains, in particular, to a method and device for determining analyte values y(tn) correlating with the concentration to be determined. Such values are determined for consecutive points in time tn.

US Patent 7,186,973. Ion trap/time-of-flight mass analyzing apparatus and mass analyzing method. Inventors: Yasushi Terui; Toyoharu Okumoto; Tsukasa Shishika; Shinji Nagai; Masaru Tomioka. Assignee: Hitachi High-Technologies.
Invention pertains to an ion trap TOF/MS able to calibrate the observed mass for each of an ion trap and a TOF. In the mass spec, sample ions having known mass numbers and ionized by an ion source are trapped within an ion trap. Unwanted ions are expelled from the ion trap via an auxiliary AC voltage having a frequency component applied to the end cap electrodes of the ion trap.
Measurement is done by applying DC voltages to the ring electrode and the end cap electrodes to expel an ion remaining in the ion trap, then measuring the mass number of the expelled ion by the TOF MS. The measurement process is repeated while changing the frequency component. The ion signal measured by the TOF MS is compared with a previously stored threshold.

US Patent 7,186,972. Time-of-flight mass analyzer having improved mass resolution and method of operating same. Inventor: Vincent Farnsworth. Assignee: Beckman Coulter.
Invention pertains to a TOF MS with improved mass resolution but without a mandated increase in size.

US Patent 7,183,118. Methods for quantitative proteome analysis of glycoproteins. Inventors: Rudolf Aebersold. Hui Zhang. Assignee: The Institute for Systems Biology.
Invention pertains to a method for identifying and quantifying polyglycopeptides in a sample. “The method can include the steps of immobilizing glycoproteins to a solid support; cleaving the immobilized glycoproteins, thereby releasing non-glycosylated peptides and retaining immobloized glycopeptides; releasing the glycopeptides from the solid support; and analyzing the released glycopeptides,” according to the abstract, and can include identification of one or more glycopeptides using mass spectrometry.

US Patent 7,183,116. Methods for isolation and labeling of sample molecules. Inventors: Rudolf Aebersold; Huilin Zhou; Beate Rist; George J. Vella; Subhasish Purkayastha; Sasi Pillai. Assignee: The Institute for Systems Biology; University of Washington; Applera.
The invention pertains to methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more functional groups, and a relative group for the same sample molecule. 

US Patent 7,179,655. Protein profiling platform. Inventors: Matthew Patricelli. Assignee: Activx Biosciences.
Inventors describe methods and compositions for analyzing complex protein mixtures. Probes that specifically react with and bind to the active form of target proteins are used. The methods can be used to get diagnostic information about disease states, identifying proteins with potential therapeutic use, and discover new drugs, according to the abstract.

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.