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Recent Patents of Interest in Proteomics: May 29, 2008

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US Patent 7,378,280. Apparatus and methods for conducting assays and high throughput screening. Inventors: Stephen Quake; Marc Unger; Hou-Pu Chou; Todd Thorsen; Axel Scherer. Assignee: California Institute of Technology
 
Microfluidic devices and methods for using them are provided. In particular, the devices are useful in conducting a variety of assays and high-throughput screening and include elastomeric compounds and comprise a main flow channel, multiple branch flow channels, multiple control channels, and multiple valves.
 

 
US Patent 7,378,263. In vivo site-specific incorporation of N-acetyl galactosamine amino acids in eubacteria. Inventors: Peter Schultz; Sarah Hanson; Ran Xu; Zhiwen Zhang; Chi-Heuy Wong. Assignee: The Scripps Research Institute
 
Described are methods and composition for making glycoproteins, both in vivo and in vitro. One method entails incorporating an unnatural amino acid having N-acetylgalactosamine moiety into a protein. “Optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars,” according to the patent’s abstract.
 

 
US Patent 7,378,056. Circuits for in vivo detection of biomolecule concentrations using fluorescent tags. Inventor: Robert Black. Assignee: Sicel Technologies
 
Pertains to methods of inserting labeled antibodies in vivo to tissue having antigens that bind specifically to the labeled antibody. A first optical radiation is emitted into the tissue in vivo, exciting the labeled antibody bound to the antigen in vivo. A second optical radiation emitted to the excited labeled antibody, responding to the excitation, can be detected in vivo.
 

 
US Patent 7,373,256. Method for the identification of molecules and biomarkers using chemical, biochemical and biological data. Inventors: Jeremy Nicholson; Elaine Holmes; Olivier Cloarec; Derek Crockford; John Lindon; Mattias Rantalainen. Assignee: N/A
 
Pertains to multivariate statistics, in particular new methods for analyzing chemical, biochemical, and biological data including spectral data.
 

 
US Patent 7,371,514. Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry. Inventors: Barry Boyes, Gordon Nicol; Hongbin Liu. Assignee: Agilent Technologies
 
The derivatizations of analytes by chemical reactions enhance the use of mass spectrometry techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by MS/MS. Mass analysis techniques are also described for sequencing polypeptides and for sequencing data in protein analysis.

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