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Recent Patents of Interest in Proteomics: Apr 26, 2007

US Patent 7,208,573. Enrichment of phosphate peptides for proteomic analysis. Inventor: Karla Robotti. Assignee: Agilent Technologies
Invention pertains to a method for separating phosphorylated peptides from a mixture of phosphorylated and unphosphoryated peptides. A kit is included in the invention. According to the abstract, a collection of peptides, some with one or more phosphate groups, is reacted with a first resin. They are then reacted with a capture ligand, which reacts with the phosphate group of the phosphorylated peptides to form a bond. Phosphorylated peptides are separated from unphosphorylated peptides with the capture ligand.

 US Patent 7,208,268. Differential phage capture proteomics. Inventor: Paul Stroobant. Assignee: Not available
Invention pertains to methods of identifying, isolating, and capturing proteins and other biomolecules “differing between two complex biological samples using affinity chromatography and phage display techniques,” according to the abstract.

US Patent 7,202,471. Method and apparatus for mass spectrometry. Inventors: Toshinobu Hondo; Jun Tamura. Assignee: JEOL
The method starts with gaining a total ion chromatogram via mass spectrometry. A desired mass peak from the displayed accumulation mass spectrum is chosen. “Another mass chromatogram coincident in elution start time, maximum elution time, and elution end time with the mass chromatogram of the selected mass peak are extracted and selected out as a mass peak,” according to the abstract, and a mass spectrum of a single component is reconstructed.

US Patent 7,202,358. Methods for producing ligand arrays. Inventor: John Hargreaves. Assignee: Not available
Invention pertains to methods of producing ligand arrays, including those with proteomic applications.

US Patent 7,202,093. Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds. Inventors: Tohru Koike; Akihiko Kawasaki; Tatsuhiro Kabashi; Makoto Takahagi. Assignee: Kabushiki Kaisha Nard Kenkyusho
Invention pertains to a method for detecting phosphorylated peptides in samples derived from living organisms, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and useable in the methods.

US Patent 7,202,076. Label-free high-throughput optical technique for detecting biomolecular interactions. Inventors: Brian Cunningham; Jane Pepper. Assignee: SRU Biosystems
Invention pertains to methods and compositions for detecting biomolecular interactions. Labels are not required and the methods can be performed in high throughput

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.