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Recent Patents of Interest in Proteomics: Jun 21, 2007

US Patent 7,232,689. Calibration procedure for investigating biological systems. Inventor: Janusz Pawliszyn. Assignee: N/A
Invention describes the use of calibrant in extraction phase for quantification of components of interest in samples. The method pertains is for both laboratory application as well as on-site monitoring. The approach is of particular utility for in vivo investigation of living systems, according to the patent.

US Patent 7,231,390. Apparatus and method for providing sequence database comparison. Inventors: Douglas Blair, John Grefenstette; Hadon Nash; Dale Newfield; Dustin Lucien. Assignee: Parabon Computation
Invention pertains to a method and system of comparing a query and subject database using a distributed computing platform. The databases are divided into data elements with sizes within a specified range. Data elements and task definitions are sent to a master CPU of a master-slave distributed computing platform. Data elements are sent alternative from query and subject data elements and a task definition is sent for each task from a master CPU to one of several slave CPUs. Data elements are send to CPUs for performance of the tasks. The task results for each task are returned to a CPU.

US Patent 7,231,328. Apparatus and methods for designing proteins and protein libraries. Inventor: John Desjarlais; Assignee: The Penn State Research Foundation
Invention pertains to a method for automated protein design. The method is applicable to the design and analysis of protein structures and protein sequences.

US Patent 7,231, 301. Method and a system for prediction protein functional site, a method for improving protein function, and a function-modified protein. Inventor: HirofumiDoi; Hideaki Hiraki; Akio Kanai. Assignee: Japan Science and Technology Corporation
Invention pertains to a method of predicting a protein functional site, “comprising the steps of calculating the frequence of occurrence of an oligopeptide in the entire proteins, calculating the value of each amino acid residue contributing to the frequence of occurrence as the representative value of the function, and predicting the protein functional site by using the representative value of function as an indicator,” according to the abstract.

US Patent 7,228,239. Methods and systems for classifying mass spectra. Inventor: Lucio Cetto. Assignee: The Mathworks
Invention pertains to methods and systems for classifying mass spectra in order to discriminate the absence or existence of a condition. It includes determining a first or higher order derivative of the signals of the mass spectra, or any linear combination of the signal, to form a mass spectra data set. The mass spectra data set is provided as input to train a classifier. The classifier trained with the derivative-based mass spectra set then classifies mass spectra samples to improve discrimination between the absence or existence of a condition.

US Patent 7,223,609. Arrays for multiplexed surface plasmon resonance detection of biological molecules. Inventors: David Anvar; Heidi Reynolds. Assignee: Agilent Technologies
Invention pertains to arrays for multiplexed evanescent scanning by allowing for high contrast surface plasmon resonance images.

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.