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Recent Patents of Interest in Proteomics: Aug 16, 2007

US Patent 7,256,259. Methods for ligation of molecules to surfaces. Inventors: Ronald Raines; Matthew Soellner. Assignee: Wisconsin Alumni Research Foundation
Invention is a method for the covalent ligation of one or more molecules to one or more surfaces. The ligation to the surface is based on the reaction of an azide and phosphinothioester to form an amide bond.

US Patent 7,255,999. Methods and compositions for analyzing proteins. Inventors: Sharat Singh; Hossein Salimi-Moosavi; Syed Hasa Tahir; Gerald Wallweber; Hrair Kirakossian; Tracey Matray; Vincent Hernandez. Assignee: Monogram Biosciences
Invention pertains to methods, compositions, and kits for determining one or more target polypeptides in a sample where the target polypeptide has undergone post-translational modification.

US Patent 7,253,404. Median filter for liquid chromatography-mass spectrometry data. Inventor: Curtis Hastings. Assignee: PPD Biomarker Discovery Services
Invention pertains to filtering of chromatography-mass spectrometry data to reduce high-intensity, spike noise. A non-linear filter, such as a moving median filter, is applied to “individual mass chromatograms, plots of ion abundance versus retention time for each detected mass-to-charge ration, and the filtered chromatograms are combined to form a filtered total ion current chromatogram,” according to the abstract.

US Patent 7,252,952. In vivo production of cyclic peptides for inhibiting protein-protein interaction. Inventors: James Lorens; Todd Kinsella; Todd Pray; Mark Bennett. Assignee: Rigel Pharmaceuticals
The invention pertains to methods and compositions using inteins for the generation of libraries of cyclic peptides in vivo. Methods of inhibiting protein-protein interaction are also described.

US Patent 7,250,097. Device for sequential protein transfer from a gel. Inventors: Jo Antal; Zsuzsanna Buzas; Andreas Chrambach. Assignee: US Department of Health and Human Services
The invention describes an apparatus and method for sequentially electroeluting biomolecules. The apparatus comprises a separation medium having an outlet and a collector with “at least a first receptacle and a second receptacle that can be sequentially brought into contact with the outlet of the separation medium by translating the first receptacle and the second receptacle in relation to the outlet of the separation medium,” according to the abstract.
The method involves receiving a first substantially separated molecule in the first receptacle and translating the first and second receptacle such that the second receptacle is brought in contact with the outlet of the separation medium. A substantially separated molecule is received in the second receptacle and the steps are repeated to sequentially receive a desired number of substantially separated molecules.

US Patent 7,247,490. Method for screening crystallization conditions in solution crystal growth. Inventor: Lawrence DeLucas. Assignee: The University of Alabama at Birmingham Research Foundation
Invention describes a method for screening protein crystal growth conditions with pictogram to microgram amounts of protein in picoliter or nanoliter volumes. It comprises a microarray with a plurality of microchambers in the microarray. The protein crystal growth is placed in the microchambers by an automated dispensing mechanism and the protein growth conditions of each microchamber is adjusted so that growth conditions in at least two of the microchambers differs. “Crystallization of the protein solution in the microchambers is effected. Protein crystal growth in the microchambers is then observed,” according to the abstract.

US Patent 7,247,469. Non-specific binding resistant protein arrays and methods for making the same. Inventors: Peter Wagner; Peter Kernen; Hongbo Lu; Huu Tran. Assignee: Zyomyx
Invention pertains to arrays of protein-capture agents and methods of making and using them. The arrays are useful for the simultaneous detection of a plurality of proteins, which are either expression products or fragments thereof, of a cell or population of cells in an organism.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.