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Recent Patents of Interest in Proteomics: Oct 4, 2007

US Patent 7,277,799. Isotope correlation filter for mass spectrometry. Inventor: Melvin Park. Assignee: Bruker Daltonics
Invention pertains to mass spectrometry and the analysis of chemical samples. It includes a method for filtering low-intensity mass spectral data, and more specifically a method for use with “digitized mass spectra that facilitates the distinction between low level signals and noise using the correlation of signals therein based on their mass differences,” according to the abstract.

US Patent 7,276,381. Monomers and polymers having energy absorbing moieties of use in desorption/ionization of analytes. Inventor: Naotaka Kitagawa. Assignee: Bio-Rad Laboratories
Invention pertains to polymerizable monomers incorporating moieties derived from energy-absorbing molecules. Polymers based on the monomers are also provided. The polymers have properties that make them suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes, according to the abstract.

US Patent 7,276,378. Increasing ionization efficiency in mass spectrometry. Inventor: Joel Myerson. Assignee: Agilent Technologies
Invention pertains to a system of analysis of polyionic molecules by mass spectrometry. A polyionic molecule is attached to a charged tag, which neutralizes some of the charge of the polyionic analyte. The adduct with a reduced net charge is then analyzed by mass spectrometry. The determined molecular weight of the adduct can be used to calculate the molecular weight of the analyte.

US Patent 7,274,014. Apparatus and method for adjustment of ion separation resolution in FAIMS. Inventors: Maria Guevremont; James Kapron; Roger Guevremont. Assignee: Thermo Finnigan [now Thermo Fisher Scientific]
Invention pertains to an apparatus for “controllably varying specificity of a FAIMS-based ion separation.” A FAIMS (high- Field Asymmetric waveform Ion Mobility Spectrometry) analyzer region defined between a first electrode surface and a second other electrode surface is included.

US Patent 7,271,896. Detection of biomolecules using porous biosensors and Raman spectroscopy. Inventors: Selena Chan; Tae-Woong Koo. Assignee: Intel
Methods are provided for the analysis of a biological sample with cascade Raman sensing. A fluorescence-producing nanoporous biosensor with probes that bind to known analytes is contacted with a biological sample. After complexes coupled to the porous semiconductor structure are formed, they are contacted with a Raman-active probe binding specifically to the bound complexes. The biosensor is illuminated to generate fluorescent emissions from the biosensor. Raman signals from the bound complexes are generated by the fluorescent emissions. The Raman signals produced by the bound complexes are detected and the signal associated with a bound protein-containing analyte indicates the presence of the protein-containing compound in the sample.

US Patent 7,271,397. Combined chemical/biological agent detection system and method utilizing mass spectrometry. Inventors: Wayne Bryden; Robert Cotter; Scott Ecelberger. Assignee: The Johns Hopkins University
A mass spectrometer is configured to have two ionization sources. The first is capable of providing a set of normally intractable desorbed neutrals in addition to ions. The neutrals are ionized by a second electron beam source coupled with the first source.

US Patent 7,262,283. Method for extracting proteins. Inventors: Robertus Hendriks; Afsaneh Abdolzade-Bavil. Assignee: Merck Patent
Invention pertains to a method and kit for the sequential extraction of proteins to be used for producing partial proteomes from a complete proteome.

US Patent 7,258,981. Sensitive proteasome sensor constructs and methods for their design and use. Inventors: Pierre Turpin; Yu Fang. Assignee; Clontech Technologies
Invention pertains to methods for sensing proteasome activity and other degradation pathways “with a high level of sensitivity,” according to the abstract.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.