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Recent Patents of Interest in Proteomics: Nov 21, 2007

US Patent 7,299,134. Method for correlating gene expression profiles with protein expression profiles. Inventors: William Rich; William Hutchens. Assignee: Bio-Rad Laboratories
Invention pertains to methods for correlating gene and protein expression in a cell.

US Patent 7,298,477. Method and apparatus for detecting biomolecular interactions. Inventors: Brian Cunningham; Peter Li; Frank DiFilippi. Assignee: SRU Biosystems
The method does not call for the use of labels and can be done in high-throughput manner. The apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. An optical fiber is coupled to the light source, illuminating the biosensor, and a second optical fiber detects a wavelength reflected from the biosensor. “A spectrometer determines spectra of a reflected signal from the biosensor,” the inventors say in the patent abstract.

US Patent 7,297,941. Methods for improved data dependent acquisition. Inventors: Michael Senko; Eric Hemenway; Tina Hemenway. Assignee: Thermo Scientific
Mass spectral scans are taken of a sample eluted from an LC column. An extracted ion chromatogram is created for each m/z data point of the mass spectral scans. Each extracted ion chromatogram is correlated to a model function. A weighting function is applied to the extracted ion chromatogram correlation value to get a current weighted intensity. The current weighted intensity for each m/z point is then used to reconstruct a weight mass spectrum. The spectrum is used to make a real-time decision for the data dependent acquisition.

US Patent 7,297,501. Method and devices for running reactions on a target plate for MALDI spectrometry. Inventors: Scott Diamond; Dhaval Gosalia. Assignee: University of Pennsylvania
Invention pertains to a peptide or protein method and apparatus in which varieties of chromogenic or fluorogenic peptide or protein substrates are individually suspended or dissolved in a hydrophilic carrier. Aliquots of each substrate are deposited in an array or microarray of reaction loci or “dot.” Each dot provides an individual reaction chamber with the peptide or protein of interest. A biological sample may be applied to each dot for assay purposes.

US Patent 7,294,704. Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk. Inventors: Iris Simon; Laura Corral; Charis Lawrenson; Nam Kim; Glenn Pilkington; Robert Wolfert. Assignee: diaDexus
Invention pertains to a method utilizing the Pro 108 and prostate specific antigen test in combination to assess the risk of prostate cancer. The invention also describes a method for assessing the risk for ovarian, colon, breast, or stomach cancer using Pro108 or specific antibodies to Pro108. 

US Patent 7,294,472. Methods for identifying modulators of G protein coupled receptor signaling. Inventors: Annette Gilchrist. Heidi Hamm; Assignee: Caden Biosciences
The invention pertains to methods of identifying peptides and compounds that block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor.

US Patent 7294, 471. Method for purifying cancer-specific proliferating cell nuclear antigen. Inventors: Linda Malkas; Robert Hickey; Pamela Bechtel; Min Park; Derek Hoelz; Dragana Tomic; Lauren Schnaper. Assignee: csKeys
Along with a method for purifying csPCNA, an immunoassay based on the method is provided.

US Patent 7,294,456. Mass Labels. Inventors: Gunter Schmidt; Andrew H Thompson; Robert A.W. Johnstone. Assignee: Electrophoretics
Invention contains sets of mass labels. Each set contains a mass marker moiety, a mass normalization moiety, and a cleavable linker “connecting the mass marker moiety to the mass normalization moiety.” Each mass marker moiety is characterized as having a mass different from that of all other mass marker moieties in the set, determined by mass spectrometry. Each mass normalization moiety ensures that each mass label in the set has “substantially” the same mass as determined by mass spectrometry.

US Patent 7,292,336. Method and instrument for detecting biomolecular interactions. Inventors: Brian Cunningham; Peter Li. Assignee: SRU Biosystems
The invention pertains to a method and apparatus for detecting biomolecular interactions. The method does not call for the use of labels and may be done in high-throughput manner. The system includes an array of detection locations, comprising a light source for generating collimated white light. The collimated light is directed toward a surface of a sensor corresponding to the detector locations by a beam splitter. A detection system includes an imaging spectrometer that receives the reflected light and generates an image of the reflected light.

US Patent 7,291,504. Assay involving detection and identification with encoded particles. Inventor: Michael Seul. Assignee: BioArray Solutions
Invention pertains to the method and an apparatus for manipulating colloidal particles and biomolecules at the interface between an insulating electrode and an electrolyte solution. It provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size.

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Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.