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Recent Patents of Interest in Proteomics: Jan 3, 2008

US Patent 7,314,726. Beta secretase exosite binding peptides and methods for identifying beta secretase modulators. Inventors: Michael Kornacker; Robert Copeland; Joseph Hendrick; Zhihong Lai; Claudio Mapelli; Marck Richard Witmer; Jovita Marcinkeviciene; William Metzler; Ving Lee; Douglas James Riexinger. Assignee: Bristol-Myers Squibb
Invention pertains to peptides that specifically bind to BACE at a newly discovered exosite and provides methods for identifying peptides that bind to a BACE exosite. In another aspect, it provides methods for treating and preventing neurodegenerative disorders by administering compounds that bind to a BACE exosite and modulate BACE activity.

US Patent 7,312,441. Method and apparatus for controlling the ion population in a mass spectrometer. Inventors: Adrian land; Lee Earley; Mark Hardman; Rexford Heller; Michael Senko. Assignee: Thermo Finnigan (now Thermo Fisher Scientific)
A first sample of ions is provided in the mass spectrometer and a measure of the abundance of a species of interest is determined, the measure of abundance comprising an intensity value. A second ion sample is introduced in the mass spectrometer in an amount determined at least in part on the measure of abundance of the species of interest in the fist sample of ions.

US Patent 7,312,090. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor. Inventors: Bo Lin; Jane Pepper; Brian Cunningham; John Gerstenmaier; Peter Li; Jean Qui; Homer Pien. Assignee: SRU Biosystems
The methods described do not require the use of labels and can be performed in a high-throughput manner. The invention also relates to optical devices.

US Patent 7,312,060. Methods for the detection, analysis, and isolation of nascent proteins. Inventors: Kenneth Rothschild; Sadanand Gite; Jerzy Olejnik; Mark Lim. Assignee: Ambergen
Invention pertains to non-radioactive markers that allow for the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Such proteins can be “rapidly and efficiently detected isolated and analyzed without the handling and disposal problems associated with radioactive reagents,” according to the abstract.

US Patent 7,309,614. Self-referencing biodetection method and patterned bioassays. Inventors: Cheryl Baird; Brian Cunningham; Peter Li. Assignee: SRU Biosystems.
Invention pertains to methods and compositions for detecting biomolecular interactions. The use of labels is not required and detection can be done in a high-throughput manner.

US Patent; 7,309,410. Traveling wave grids and algorithms for biomolecule separation, transport, and focusing. Inventors; Meng Lean; Jeng Ping Lu; Jackson Ho; Chinwen Shih; Armin Volkel; Huangpin Ben Hsieh; Jurgen Daniel. Assignee: Palo Alto Research Center
The implementation of a vertically integrated traveling wave module is described, allowing for scalability to arbitrary gel dimensions through tiling. Several unique traveling wave algorithms are also described. Used in conjunction with the traveling wave grids, they provide selective motion to biomolecules and other charged species.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.