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ProteoMonitor s IP Roundup: Recent Patents of Interest in Proteomics: Jan 21, 2005


US Patent No. 6,841,359. Streptavidin-binding peptides and uses thereof. Inventors: Jack Szostak, David Wilson, Anthony Keefe. Assignee: The General Hospital Corporation.

This invention provides peptides with high affinity for streptavidin. These peptides may be expressed as part of fusion proteins to facilitate the detection, quantitation and purification of proteins of interest.

US Patent No. 6,835,927. Mass spectrometric quantification of chemical mixture components. Inventors: Christopher Becker, Curtis Hastings, Scott Norton. Assignee: Surromed.

With this invention, relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required.

US Patent No. 6,833,112. High performance system for the parallel and selective dispensing of micro-droplets, and transportable cartridge and dispensing using said system. Inventor: Moussa Hoummady.

This invention aims at allowing a consistent increase in the output of selective dispensing of micro-droplets, at making a spatial, targeted selectivity by distributing a predetermined reagent on the predetermined site, and at creating a multifunctional, easy to adjust system. The invention is notably applicable for the manufacturing of bio-chips, pharmaceutical, immunological, or biochemical tests, and for the screening of drug libraries or serum banks.

US Patent No. 6,831,154. Membrane-associated protein 17 KD (MAP17)-interacting protein and use thereof. Inventor: Paul Bartel. Assignee: Myriad Genetics.

In this invention, protein complexes are provided comprising MAP17 and SCAMP2. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and disorders associated with MAP17 and SCAMP2. Methods for detecting the protein complexes and modulating the functions and activities of the protein complexes, or interacting members of the complexes, are also provided.

US Patent No. 6,830,931. Method and apparatus for monitoring of proteins and cells. Inventors: Alfred Bahnson, Douglas Koebler, Charalambos Arthanassiou, Raymond Houck, Kris Sachsenmeier, Lei Qian. Assignee: Automated Cell.

This invention is an apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes a means for analyzing the effect of proteins and other biological moieties on the cells. It includes an apparatus for aligning light in a well of a plate for holding cells, a method for manipulating cells and a method for determining the condition of a cell.

US Patent No. 6,829,539. Methods for quantification and de novo polypeptide sequencing by mass spectrometry. Inventors: David Goodlett, Andrew Keller. Assignee: The Institute for Systems Biology.

This invention provides a method for determining an amino acid sequence of a polypeptide using mass spectrometry of differentially labeled polypeptides. The methods of the invention are applicable to proteome analysis of complex mixtures. They are based on comparisons of mass spectra from polypeptide samples or mixtures that have been labeled differentially according to mass. The method can be used to analyze a previously unsequenced, or de novo, polypeptide sequence.

US Patent No. 6,828,112. Method of detecting protein-protein interactions. Inventors: John Manfredi, Jay Zhang. Assignee: Myriad Genetics.

In this invention, a method for detecting protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other. The interaction between the two fusion proteins leads to trans-splicing, generating an active and detectable reporter.

US Patent No. 6,818,454. Phosphoprotein binding agents and methods of their use. Inventors: Michael Goshe, Thomas Conrads, Timothy Veenstra, Ellen Panisko. Assignee: Battelle Memorial Institute.

This invention provides reagents and methods for identifying and/or quantifying the phosphorylation states of proteins.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.