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ProteoMonitor s IP Roundup: Recent Patents of Interest in Proteomics: Oct 10, 2003


US Patent No. 6,630,358. Arrays of proteins and methods of use thereof. Inventors: Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin. Assignee: Zyomyx.

Covers protein arrays and methods of use, including screening for interactions between proteins and analytes in an applied substance such that reagent volumes and protein inactivation problems are minimized. The array contains immobilized proteins arranged in discrete regions on a substrate surface covered by an organic thinfilm. Protected methods include screening for protein interactions with solution analytes, screening for protein binding with analytes, screening for protein-protein binding, and methods of delivering sample to the array.

US Patent No. 6,629,040. Isotope distribution encoded tags for protein identification. Inventors: David Goodlett, James Bruce, Beate Rist, Richard Smith, Ruedi Aebersold. Assignees: University of Washington, Battelle Memorial Institute.

Covers methods and reagents associated with identifying specific masses of compuounds in a complex mixture using an isotope distribution encoded tag, or IDEnT, where peptides are covalently modified with a reagent specific for cysteine-containing peptides, changing the normal isotope pattern for the peptide. The tag is to be used for protein identification, enzyme active site identification, peptide sequencing, and similar processes. An alternate embodiment allows for tagging of other biomolecules including DNA, RNA, and lipids.

US Patent No. 6,627,400. Multiplexed measurement of membrane protein populations. Inventors: Sharat Singh, Tracy Matray. Assignee: Aclara Biosciences.

Covers compounds and methods for separating biopolymers using eTag reporters, which are defined as labels from a kit that link to nucleic acids or proteins and allow for assaying based on the release of the reporters from the polymer when the molecule binds with another molecule. Binding interactions can be detected this way.

US Patent No. 6,630,665. Device and method preventing ion source gases from entering reaction/collision cells in mass spectrometry. Inventors: Scott Tanner, Dmitry Bandura, Vladimir Baranov. Assignee: MDS Inc.

Covers an ion-neutral decoupling device between the ion interface and the reaction/collision cell section in a mass spectrometer. This prevents the supersonic jet entering the spectrometer from being able to cause plasma gases to penetrate into the reaction/collision cell. Also covers the method of operating the mass spectrometer using the device.


The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.