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ProteoMonitor s IP Roundup: Recent Patents of Interest in Proteomics: Jan 27, 2003

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US Patent 6,508,986. Devices for use in MALDI mass spectrometry. Inventors: Leigh Anderson, John Joseph Lennon, Jack Goodman. Assignee: Large Scale Proteomics.
Covers an alignment plate with a number of holes for guiding a pipette tip toward a sample plate of a MALDI mass spectrometer.

 

US Patent 6,507,664. Two-dimensional gels for separation, identification and characterization of biomolecules. Inventors: Leigh Anderson, Norman Anderson, Jack Goodman. Assignee: Large Scale Biology.
Protects an integrated, fully automated, high-throughput system for two-dimensional electrophoresis.

 

US Patent 6,500,671. Loading microcolums for the separation of analytes from a sample in the millisecond time scale. Inventors: David Hage, William Clarke. Assignee: The Board of Regents of the University of Nebraska.
Covers a microcolumn for separating an analyte from a sample in a millisecond time frame.

 

US Patent No. 6,498,340. Method for calibrating mass spectrometers. Inventors: Gordon Anderson, Michael Brands, James Bruce, Ljiljana Pasa-Tolic, Richard Smith. Assignee: Battelle Memorial Institute.
Involves measuring the mass-to-charge signal generated by ions within the mass spectrometer, then identifying ions of equal mass that have differing charge states, followed by adjusting the calibration parameters.

 

US Patent 6,485,984. Calixcrown derivates, a process for the preparation thereof, a self-assembled monolayer of the calixcrown derivates prepared by using the same, and a process for immobilizing a protein monolayer by using the self-assembled monolayer of the calixcrown derivatives. Inventor: Tai-Sun Kim. Assignee: Proteogen (Korea).
Covers the preparation of new calixcrown derivates and how to prepare self-assembled monolayers of them. These calixcrown derivatives possess two recognition sites that can be used as molecular linkers.

 

US Patent 6,485,623. Method and device for forming angled wells in an electrophoresis gel slab. Inventor: Leigh Anderson. Assignee: Large Scale Proteomics.
Covers a method and device for forming angled sample wells along a vertical edge of the gel slab for retaining liquid samples in a slab gel electrophoresis separation.

 

US Patent 6,482,303. Automated system for two-dimensional electrophoresis. Inventors: Leigh Anderson, Norman Anderson, Jack Goodman. Assignee: Large Scale Proteomics.
Covers an integrated, fully automated, high throughput system for two-dimensional electrophoresis.

 

US Patent 6,480,618. Robotic device for removing selected portions of a polyacrylamide gel. Inventors: Rajesh Bhikhu Parekh, Robert Amess, James Alexander Bruce, Sally Barbara Prime, Albert Edward Platt, Richard Michael Stoney. Assignee: Oxford GlycoSciences.
Protects computer-assisted methods and apparatus for identifying, selecting, and characterizing biomolecules in a biological sample.

 

US Patent 6,478,238. Miniaturized fluid transfer device. Inventors: Timothy Wachs, Jack Henion. Assignee: Cornell Research Foundation.
Covers a miniaturized ion sprayer device that is suitable for coupling with chip-based analytical separation devices, multi-well plates, or surfaces containing residues of prepared samples.

 

US Patent 6,475,808. Arrays of proteins and methods of use thereof. Inventors: Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin. Assignee: Zyomyx.
Covers protein arrays for parallel, in vitro screening of biomolecular activity and methods for their use.

 

US Patent 6,468,346. Applying x-ray topography and diffractometry to improve protein crystal growth. Inventors: Leonard Arnowitz, David Black, Travis Gallagher. Assignee: BSI Proteomics.
Covers a method for identifying improved conditions for growing protein crystals.

 

US Patent 6,459,994. Methods for computer-assisted isolation of proteins. Inventors: Rajesh Bhikhu Parekh, James Alexander Bruce, Robin Philp, Lida Kimmel, David Friedman. Assignee: Oxford GlycoSciences.
Protects computer-assisted methods and apparatus for identifying, selecting, and characterizing biomolecules in a biological sample.

 

US Patent 6,454,924. Microfluidic devices and methods. Inventors: Paul Jedrzejewski, Steffen Nock, Peter Wagner, Pierre Indermuhle, Frank Zaugg. Assignee: Zyomyx.
Covers microfluidic devices. In one embodiment, a microanalysis chip has at least one transfer-separation channel with a bottom opening.

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