US Patent 6,580,071. Method for calibrating a mass spectrometer. Inventors: Scot Weinberger, Edward Gavin, Michael Youngquist. Assignee: Ciphergen Biosystems.
Covers a method for calibrating a time-of-flight mass spectrometer. Time-of-flight values are determined for a calibration substance at different addressable locations on a sample substrate. One of these locations is then identified as a reference location. After that, correction factors are calculated for the respective locations on the substrate using the time-of-flight value.