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ProteoMonitor s IP Roundup: Recent Patents of Interest in Proteomics: Jul 1, 2005


US Patent No. 6,900,431. Multiplexed orthogonal time-of-flight mass spectrometer. Inventors: Mikhail Belov, Charles Fancher, Peter Foley. Assignee: Predicant Biosciences.

This invention is a device and method for characterizing sample materials. It provides a time-of-flight mass spectrometer that allows overlapping packets of ions to be mathematically resolved into a mass spectrum. Differing quantities of ions can be accumulated in the sequential pulses according to a pseudo-random sequence, and the slower ions are overtaken by the faster ions of a subsequent pulse. A mass spectrum may be reconstructed from an overlapping ion detector signal using an inverse of a weighted simplex matrix or inverse Hadamard transform techniques.

US Patent No. 6,900,061. MALDI plate and process for making a MALDI plate. Inventors: Igor Smirnov, Andrew Tomlinson, Lawrence Haff, Jennifer Campbell, Cheryl Murphy. Assignee: PerSeptive Biosystems, MDS.

This invention provides a MALDI sample plate with a hydrophobic coating whose thickness and hydrophobic character can be modified by changing the coating substrate and/or concentration of the substrate. Coating substances include synthetic waxes such as paraffin compositions, lipids, organic acids, silicon-containing compounds, silica polymers and natural waxes.

US Patent No. 6,897,073. Non-specific binding resistant protein arrays and methods for making the same. Inventors: Peter Wagner, Peter Kernen, Hongbo Lu, Huu Tran. Assignee: Zyomyx.

This invention consists of a variety of protein-capture agent arrays, in particular antibody arrays, and methods of both making and using the arrays.

US Patent No. 6,897,020. Methods and compositions for elucidating relative protein expression levels in cells. Inventors: Charles Link, Tatiana Seregina, Nicholas Vahanian, James Higginbotham, Jay Ramsey, Bradley Powers, Sachet Shukla, Won Bin Young. Assignee: NewLink Genetics.

This invention enables the direct correlation of genomic DNA to rapidly quantifiable protein expression levels enabling a protein expression profile for a particular cell. This information can then be used to correlate with reference cells to identify differences in protein expression patterns that may be responsible for different cell types, tissue types, disease states, or other cellular differences desirable for use in diagnostics, or for drug therapy targets.

US Patent No. 6,896,894. Proteins stabilized with polysaccharide gums. Inventors: Richard Brody, Sreedhara Alvattam. Assignee: Battelle Memorial Institute.

This invention describes heat-stable, aqueous solutions or gels comprising a biologically effective amount of a protein and an effective stabilizing amount of a polysaccharide gum, as well as heat-stable solutions or gels suitable for use in an implantable drug delivery device at body temperature.

US Patent No. 6,887,851. IGF-binding protein-derived peptide. Inventor: Desmond Mascarenhas. Assignee: Bioexpertise.

In this invention, new compositions based on IGF-binding protein sequences are provided, along with new tools for high-throughput research.

The inventor has found that IGFBP-3, or peptides containing part of the human IGFBP-3 sequence, can exhibit a large number of useful physical and biological properties. In particular, the inventor has demonstrated that the CD-74-like domain of IGFBP-3 exhibits the ability to selectively bind metals such as zinc and nickel. In this invention, short peptides called "MBD peptides", containing just 12-22 amino acids from the C-terminal domain of IGFBP-3, are presented as an alternative to the use of full-length IGFBP-3.

US Patent No. 6,884,575. Phosphoprotein target for insulin and its antagonists. Inventors: Garth Cooper, Aimin Xu, Yu Wang. Assignee: Protemix.

This invention provides methods for diagnosing and treating individuals with insulin resistance. The invention relates to a phosphoprotein target that exhibits distinct phosphorylation patterns in response to insulin and its antagonists in certain disease states.

The Scan

UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer

A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways.

Survey Sees Genetic Literacy on the Rise, Though Further Education Needed

Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds.

Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors

Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers.

FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands

The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.