US Patent No. 6,610,472. Assembly and screening of highly complex and fully human antibody repertoire in yeast. Inventors: Li Zhu, Shaobing Hua, James Sheridan, Yu-Huei Lin. Assignee: Genetastix.
Covers compositions, methods, and kits for generating a library of protein complexes and conducting high-throughput screens to pull out those that bind other proteins or oligos. One feature allows the self-assembly in vivo of protein complexes by expressing protein components with separate expression vectors and then introducing them into cells.