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ProteoMonitor s IP Roundup: Recent Patents of Interest in Proteomics: Jul 2, 2004


US Patent No. 6,756,586. Methods and apparatus for analyzing biological samples by mass spectrometry. Inventor: Richard Caprioli. Assignee: Vanderbilt University.

Covers methods and apparatuses for analyzing proteins and other molecules within a sample. A specimen is struck with laser beams so that it releases proteins, and the atomic mass range is measured. The atomic mass range is analyzed to determine the spatial arrangement of the proteins in the sample and the proteins are identified as a function of the arrangement.

US Patent No. 6,753,142. Methods and compositions for elucidating relative protein expression levels in cells. Inventors: Charles Link, Tatiana Seregina, Nicholas Vahanian, James Higginbotham, Jay Ramsey, Bradley Powers, Sachet Shukla, Won Bin Young. Assignee: NewLink Genetics.

Covers methods and compositions for identifying differential protein expression patterns as well as active genetic regions involved in different cell types, tissue types, disease states, etc. The invention includes a method of encoding a tag protein into the genome of an organism. The activity of the tag is measured in order to sort and quantify protein expression patterns for the cell.

US Patent No. 6,750,076. Fabrication of a microchip-based electrospray device. Inventor: Thomas Corso. Assignee: Advion Biosciences.

Covers a method for making a microchip-based electrospray device. The method includes using a primary mask to define the nozzle feature, and a secondary mask to construct the through channel. The primary mask is then defined and etched, and the secondary mask masks given areas of the primary mask for more etching. The through hole of the secondary mask has a slightly larger diameter than that for the primary mask and aligns over the primary mask’s channel.

US Patent No. 6,753,523. Mass spectrometry with multipole ion guides. Inventors: Craig Whitehouse, Bruce Andrien, Erol Gulcicek. Assignee: Analytica.

Covers an instrument with multiple ion guides that are operated in mass-to-charge selection and ion fragmentation modes. The ion guides are mounted in a linear fashion with no electrodes between them. At least a portion of each guide resides in a vacuum region with higher background pressure, and at least one guide can be configured to extend continuously from one vacuum stage to another. The presence of higher background pressure for one guide allows for CID fragmentation, by axially accelerating ions from one guide another. A variety of MS and MS/MS functions can be performed using this set-up.

US Patent No. 6,753,522. FAIMS apparatus having plural ion inlets and method therefore. Inventors: Roger Guevremont, Randy Purves, David Barnett. Assignee: Ionalytics.

Covers an apparatus including a high field asymmetric waveform ion mobility spectrometer (FAIMS) with an inner electrode; and a method for using it to separate ions. The apparatus also includes an outer electrode that surrounds the inner electrode over at least part of the length of the inner electrode, with ions propagating between the electrodes. The outer electrode also includes an at least a first and second ion inlet into the analyzer region, and an outlet from the analyzer. The electrodes provide an electric field within the analyzer region resulting from the application of asymmetric waveform voltage to at least one of the electrodes and of a compensation voltage to one of the electrodes.

US Patent No. 6,753,521. Method and apparatus for a nanoelectrosprayer for use in mass spectrometry. Inventors: Melvin Park, Houle Wang. Assignee: Bruker Daltonics.

Covers a nanospray device for use with a mass spectrometer. The device is composed of a base, union, retainer, nanospray needle, entrance cap, first capillary section, and union. The nanospray device is integrated with the rest of the ion source by joining of the first capillary section, which is in the nanospray device, with a second capillary section in the body of the source.

US Patent No. 6,750,448. Preparative separation of mixtures by mass spectrometry. Inventors: Frantisek Turacek, Adi Scheidemann, Terry Olney, Frank Schumacher, Martin Smrcina, Peter Strop, Marcel Patek, Danile Schirlin. Assignee: University of Washington, Aventis Pharmaceuticals.

Covers an instrument and methods for using mass spectrometry to do preparative separation of a mixture. Nondestructive ionization methods generate ionized components that are then mass-separated and rapidly accumulated in nanomole quantities.

US Patent No. 6,750,061. Method and product for the sequence determination of peptides using a mass spectrometer. Inventors: Brian Chait, Ronald Beavis, Rong Wang, Stephen Kent. Assignee: Rockefeller University, Scripps Research Institute.

Covers a method for sequencing polypeptides by forming peptide ladders that consist of a series of polypeptides in which the adjacent members vary by one amino acid. The identify and position of each amino acid is then determined by mass spectrometry.

US Patent No. 6,747,274. High throughput mass spectrometer with laser desorption ionization ion source. Inventor: Ganggiang Li. Assignee: Agilent Technologies.

Covers a laser desorption/ionization mass spectrometer that uses an ion source with a plurality of lasers firing in tandem at one or more samples. This tandem firing increases the rate of ion generation in the source.

US Patent No. 6,747,271. Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisition. Inventors: Marc Gonin, Valeri Raznikov, Katrin Fuhrer, Albert Schultz, Michael McCully. Assignee: Ionwerks.

Covers a detection system for TOF mass spectrometers that extends the dynamic range without crosstalk. The invention uses secondary amplification or different primary amplification stages to overcome the limitation of the amount to which dynamic range can be increased given crosstalk between anodes.

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.