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ProteoMonitor s IP Roundup: Recent Patents of Interest in Proteomics: Feb 2, 2006

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US Patent No. 6,989,531. Mass spectrometer. Inventors: Atsumu Hirabayashi, Masako Ishimaru, Masahiro Yamaoka. Assignee: Hitachi High-Technologies.

The invention relates to a liquid chromatograph/mass spectrometer that separates and analyzes liquid mixture. In particular, the invention relates to a protein analysis system and a glycan analysis system. The LC/MS interface has a structure so that the end of the spray capillary is rarely damaged. A metallic device that has a hole for connecting a separation column, a spray capillary, and a resin member for fixing the upstream side of the short spray capillary are used.


US Patent No. 6,989,528. Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues. Inventors: Albert Schultz, Mechael Ugarov, Thomas Egan, Agnes Tempez, Yvon Le Beyec, Serge Della-Negra. Assignee: Ionwerks.

This invention relates to a system and method for the mass spectrometric profiling of tissue or other biopolymer or polymeric material. The method uses MALDI ionization.


US Patent No. 6,989,100. Methods for time-alignment of liquid chromatography-mass spectrometry data. Inventor: Scott Norton. Assignee: PPD Biomarker Discovery Sciences.

The invention relates to the analysis of data collected by analytical techniques such as chromatography and mass spectrometry. In particular, the invention addresses methods for time-aligning multi-dimensional chromatograms of different samples to enable automated comparison among sample data.


US Patent No. 6,974,702. Fourier transform mass spectrometry of complex biological samples. Inventors: Jean-Louis Dasseux, Roger Newton, Thomas Rea, Charles Bisgaier, Michael Pape. Assignee: Esperion Therapeutics.

The invention relates to methods for high information content analysis or screening of complex biological systems using Fourier transform mass spectrometry. The methods are useful for analyzing complex biological mixtures, and permit the identification of biologically active molecules.


US Patent No. 6,967,323. Mass spectrometer. Inventors: Yuichiro Hashimoto, Takashi Baba, Hideki Hasegawa, Izumi Waki. Assignee: Hitachi High-Technologies.

This invention relates to an ion trap mass spectrometer that comprises an ionization source for generating ions, a linear-trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time.


US Patent No. 6,989,534. Method and device for the capture of ions in quadrupole ion traps. Inventors: Michael Schubert, Jochen Franzen. Assignee: Bruker Daltonik.

This invention relates to methods and devices for capturing externally generated ions in a radio frequency operated quadrupole ion trap. The invention involves applying a voltage consisting of positive and negative pulses, instead of a sinusoidal RF voltage, during the capturing process. Capturing intervals are between each pulse in which the voltage is low.


US Patent No. 6,989,530. Ambient pressure matrix-assisted laser desorption ionization apparatus and method of analysis. Inventors: Jian Bai, Steven Fischer, Michael Flanagan. Assignee: Agilent Technologies.

A mass spectrometer having a MALDI source that operates at ambient pressure is disclosed. The invention relates to an apparatus and a method for ionizing at least one analyte in a sample for delivery to a mass analysis device.

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.