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Proteome Sciences Wins $850K to ID Biomarkers for Monitoring Effects of Environmental Pollutants


Proteome Sciences said this week it has received a £530,058 ($848,993) grant from the European Union's Framework Seven program for work on the £6.99 million DENAMIC (Developmental Neurotoxicity Assessment of Mixtures in Children) research project, which aims to develop tools for monitoring the neurotoxic effects of environmental pollutants on the cognitive skills and development of children.

Over the next two years the company will investigate the effects of neurotoxic chemicals on proteins, peptides, and biochemical pathways in cell models and tissue to build a database of protein biomarkers linked to various types of chemical exposure.

It plans to use its tandem mass tagging, or TMT, technology combined with mass spectrometry to develop the biomarker assays.

The grant follows on Proteome Sciences' participation in the EU Framework Six Sens-it-iv research project, for which the company did proteomic work investigating in vitro alternatives to animal tests currently used to assess potential skin and lung allergic reactions (PM 05/15/2008).

The Scan

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.

Family Genetic Risk Score Linked to Diagnostic Trajectory in Psychiatric Disorders

Researchers in JAMA Psychiatry find ties between high or low family genetic risk scores and diagnostic stability or change in four major psychiatric disorders over time.

Study Questions Existence of Fetal Microbiome

A study appearing in Nature this week suggests that the reported fetal microbiome might be the result of sample contamination.

Fruit Fly Study Explores Gut Microbiome Effects on Circadian Rhythm

With gut microbiome and gene expression experiments, researchers in PNAS see signs that the microbiome contributes to circadian rhythm synchronicity and stability in fruit flies.