Skip to main content
Premium Trial:

Request an Annual Quote

Proteome Sciences and Kings College ID Protein Markers for Stratifying Liver Cancer Patients

Premium

Proteome Sciences said this week that the company has in collaboration with researchers at Kings College Hospital NHS Foundation Trust identified and validated protein biomarkers for patient stratification in liver cancer.

Detailed in a paper published this week in EuPa Open Proteomics, the work used Proteome Sciences' mass spec-based proteomics services to identify markers for distinguishing between hepatocellular carcinoma and cholangiocarcinoma.

The two conditions require different treatments, but are currently difficult to tell apart based on histological analysis, Ian Pike, chief operating officer of Proteome Sciences, told ProteoMonitor. "So what is really needed are some molecular markers that can highlight the specific regions that are hepatocellular or cholangiocellular to identify if a tumor is one or the other or a mix."

In collaboration with Kings College researcher Nigel Heaton, the company analyzed 55 formalin-fixed paraffin-embedded samples, identifying a panel of five proteins that distinguished between the two conditions, two of which they validated in 10 samples using immunohistochemistry, finding that they were diagnostic in seven of those 10.

Proteome Sciences and the Kings College Hospital NHS Foundation Trust have filed patents covering the markers. The next step, Pike said, "is a larger scale validation in retrospective samples."

In terms of commercialization, the company aims ultimately to license the markers to a firm in the IHC space, he said.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.