Prion-Like P53

Premium

In its normal form, the protein p53 suppresses tumor formation, but when its gene is mutated — as it is in about half of all human cancers — the protein no longer functions as a tumor suppressor, and it can instead negatively affect wild-type p53. In a study in the Journal of Biological Chemistry published in June, researchers in Brazil report that this dominance of mutated p53 happens in part because the protein aggregates into prion-like amyloid oligomers and fibrils.

Get the full story with
GenomeWeb Premium

Only $95 for the
first 90 days*

A trial upgrade to GenomeWeb Premium gives you full site access, interest-based email alerts, access to archives, and more. Never miss another important industry story.

Try GenomeWeb Premium now.

Already a GenomeWeb Premium member? Login Now.
Or, See if your institution qualifies for premium access.

*Before your trial expires, we’ll put together a custom quote with your long-term premium options.

Not ready for premium?

Browse our free articles
You can still register for access to our free content.

In PNAS this week: genomic study of group B Streptococcus evolution, selection on the X chromosome in great apes, and more.

Changing the fat and fiber content of people's diets affects their gut microbiome, metabolome, and colon cancer risk, researchers say.

Broken links are found throughout academic publications, and some services are trying to combat such link decay.

Nick Stockton at Wired says that a pause in studying genome-editing tools should be used to find a path forward.