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In Print: Recent Proteomics Papers of Note: Aug 10, 2012

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In Print: Recent Proteomics Papers of Note

Journal: PLoS One, July 16 [Epub ahead of print]

Title: First insight into the kinome of human regulatory T cells.

Authors: König S; Probst-Kepper M; Reinl T; Jeron A; Huehn J; Schraven B; Jänsch L.

The researchers profiled the kinome of human CD4(+) T cells, obtaining quantitative information on 185 kinases and identifying 11 protein kinases that were differentially expressed in regulatory T cells compared to T effector cells.


Journal: OMICS, July 17 [Epub ahead of print]

Title: A critical appraisal of techniques, software packages, and standards for quantitative proteomic analysis.

Authors: Gonzalez-Galarza FF; Lawless C; Hubbard SJ; Fan J; Bessant C; Hermjakob H; Jones AR.

The researchers performed a review of several of the most popular techniques for quantitative proteomics as well as an appraisal of several commonly used software packages, compiling the results in a web-based tool intended to help researchers identify appropriate software for their experiments.


Journal: Cell Reports, July 20 [Epub ahead of print]

Title: ChAP-MS: A method for identification of proteins and histone posttranslational modifications at a single genomic locus.

Authors: Byrum SD; Raman A; Taverna SD; Tackett AJ.

The authors present an unbiased approach for identifying posttranslational modifications at a specific genomic locus by isolation of a locus of interest followed by mass spec analysis. They used the technique to enrich an approximtely 1,000-base pair section of the GAL1 chromosome under transcriptionally active and repressive conditions and to identify the modifications of the bound proteins and histones.


Journal: Molecular & Cellular Proteomics, July 20 [Epub ahead of print]

Title: Proteomic analysis of menstrual blood.

Authors: Yang H; Zhou B; Prinz M; Siegel D.

The authors profiled the proteome of menstrual blood, which they suggested could prove an easily accessible non-invasive source of endometrial tissue for diagnosis of infertility or endometrial pathology.


Journal: Molecular & Cellular Proteomics, July 23 [Epub ahead of print]

Title: Discovery of O-GlcNAc-6-phosphate-modified proteins by re-analyzing large-scale phosphoproteomics data.

Authors: Hahne H; Kuster B.

The authors performed a reanalysis of a publicly available mouse brain phosphoproteome data set using their Oscore software platform for the identification of O-GlcNAc modifications, identifying 23 modified peptides corresponding to 11 modified proteins.


Journal: Journal of Nutritional Biochemistry, July 25 [Epub ahead of print]

Title: Association between the plasma proteome and serum ascorbic acid concentrations in humans.

Authors: Da Costa LA; García-Bailo B; Borchers CH; Badawi A; El-Sohemy A.

The researchers used a multiple-reaction monitoring mass spec-based approach to identify proteins associated with circulating levels of ascorbic acid, detecting associations between vitamin C and plasma proteins linked to various physiological pathways, suggesting novel physiological effects for the molecule.


Journal: Journal of Proteomics, July 26 [Epub ahead of print]

Title: A comparative 'bottom up' proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids.

Authors: Han B; Hare M; Wickramasekara S; Fang Y; Maier CS.

The authors describe a mass spec-based proteomics approach using anhydride labeling combined with hydrazine functionalized beads to detect, identify, and quantify site-specific oxylipid modifications in biological matrices. They used the technique to profile cardiac mitochrondrial samples taken from mice.


Journal: Proceedings of the National Academy of Sciences, July 31

Title: Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis.

Authors: Shimbo K; Hsu GW; Nguyen H; Mahrus S; Trinidad JC; Burlingame AL; Wells JA.

The authors used a global, unbiased quantitative N-terminomics approach to profile a variety of cell types and their response to cytotoxic drug treatment, finding that roughly 500 products of caspase cleavage and their kinetics vary significantly between cell type and treatment.

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