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In Print: Recent Proteomics Papers of Note: Aug 10, 2012


In Print: Recent Proteomics Papers of Note

Journal: PLoS One, July 16 [Epub ahead of print]

Title: First insight into the kinome of human regulatory T cells.

Authors: König S; Probst-Kepper M; Reinl T; Jeron A; Huehn J; Schraven B; Jänsch L.

The researchers profiled the kinome of human CD4(+) T cells, obtaining quantitative information on 185 kinases and identifying 11 protein kinases that were differentially expressed in regulatory T cells compared to T effector cells.

Journal: OMICS, July 17 [Epub ahead of print]

Title: A critical appraisal of techniques, software packages, and standards for quantitative proteomic analysis.

Authors: Gonzalez-Galarza FF; Lawless C; Hubbard SJ; Fan J; Bessant C; Hermjakob H; Jones AR.

The researchers performed a review of several of the most popular techniques for quantitative proteomics as well as an appraisal of several commonly used software packages, compiling the results in a web-based tool intended to help researchers identify appropriate software for their experiments.

Journal: Cell Reports, July 20 [Epub ahead of print]

Title: ChAP-MS: A method for identification of proteins and histone posttranslational modifications at a single genomic locus.

Authors: Byrum SD; Raman A; Taverna SD; Tackett AJ.

The authors present an unbiased approach for identifying posttranslational modifications at a specific genomic locus by isolation of a locus of interest followed by mass spec analysis. They used the technique to enrich an approximtely 1,000-base pair section of the GAL1 chromosome under transcriptionally active and repressive conditions and to identify the modifications of the bound proteins and histones.

Journal: Molecular & Cellular Proteomics, July 20 [Epub ahead of print]

Title: Proteomic analysis of menstrual blood.

Authors: Yang H; Zhou B; Prinz M; Siegel D.

The authors profiled the proteome of menstrual blood, which they suggested could prove an easily accessible non-invasive source of endometrial tissue for diagnosis of infertility or endometrial pathology.

Journal: Molecular & Cellular Proteomics, July 23 [Epub ahead of print]

Title: Discovery of O-GlcNAc-6-phosphate-modified proteins by re-analyzing large-scale phosphoproteomics data.

Authors: Hahne H; Kuster B.

The authors performed a reanalysis of a publicly available mouse brain phosphoproteome data set using their Oscore software platform for the identification of O-GlcNAc modifications, identifying 23 modified peptides corresponding to 11 modified proteins.

Journal: Journal of Nutritional Biochemistry, July 25 [Epub ahead of print]

Title: Association between the plasma proteome and serum ascorbic acid concentrations in humans.

Authors: Da Costa LA; García-Bailo B; Borchers CH; Badawi A; El-Sohemy A.

The researchers used a multiple-reaction monitoring mass spec-based approach to identify proteins associated with circulating levels of ascorbic acid, detecting associations between vitamin C and plasma proteins linked to various physiological pathways, suggesting novel physiological effects for the molecule.

Journal: Journal of Proteomics, July 26 [Epub ahead of print]

Title: A comparative 'bottom up' proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids.

Authors: Han B; Hare M; Wickramasekara S; Fang Y; Maier CS.

The authors describe a mass spec-based proteomics approach using anhydride labeling combined with hydrazine functionalized beads to detect, identify, and quantify site-specific oxylipid modifications in biological matrices. They used the technique to profile cardiac mitochrondrial samples taken from mice.

Journal: Proceedings of the National Academy of Sciences, July 31

Title: Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis.

Authors: Shimbo K; Hsu GW; Nguyen H; Mahrus S; Trinidad JC; Burlingame AL; Wells JA.

The authors used a global, unbiased quantitative N-terminomics approach to profile a variety of cell types and their response to cytotoxic drug treatment, finding that roughly 500 products of caspase cleavage and their kinetics vary significantly between cell type and treatment.

The Scan

Booster for At-Risk

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Preprints OK to Mention Again

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Hundreds of Millions More to Share

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