A team led by researchers at Pacific Northwest National Laboratory has devised a streamlined top-down proteomics approach that they have used to profile the pathogen Salmonella Typhimurium.

Using the workflow, which features a single dimension of chromatographic separation as opposed to the multi-dimensional separation procedures typical in top-down work, the researchers identified in Salmonella a post-translational modification – S-cysteinylation – not previously detected in gram-negative bacteria.

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