PNNL Team Develops Antibody-Free SRM-MS Method for Low-Abundance Biomarker Quantification | GenomeWeb

Researchers at Pacific Northwest National Laboratory and the National Cancer Institute have developed a new selected-reaction monitoring mass spectrometry-based technique capable of quantifying proteins at low picogram-per-mL levels without the use of immunoenrichment.

According to Wei-Jun Qian, a PNNL researcher and one of the project's leaders, the method could prove particularly useful as a targeted pre-verification step, helping fill the gap between protein biomarker discovery and clinical validation.

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