The Peptide Blockade

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Scientists have used molecular engineering techniques and a follow-up cell-based assay to block HIV entry into cells. In their work, published in August in the Proceedings of the National Academy of Sciences, they took advantage of the fact that engineered peptides can stably interact with cell surface proteins to block HIV infection of cells. In the future, the technique could be used as an alternative to current therapies that rely on antibody-based drugs, says lead author Sam Gellman, a chemist at the University of Wisconsin, Madison.

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