Skip to main content
Premium Trial:

Request an Annual Quote

NYU, Natural History Museum to Use $1.6M NSF Grant for Plant Proteome Bioinformatics Research

NEW YORK (GenomeWeb News) – The National Science Foundation has given three scientists at New York University and at the American Museum of Natural History a $1.6 million grant to study the proteomes of two plants and to place their data in a public database, NYU said on Wednesday.
 
The investigators will use the three-year grant to study the structure, evolution, and function of the proteomes of the Arabidopsis thaliana, a small flowering plant that was the first plant to have its genome sequenced, and the rice plant Oryza sativa.
 
The studies will be conducted by two biologists at NYU’s Center for Genomics and Systems Biology, Richard Bonneau and Michael Purugganan, and by Rod DeSalle at the Sackler Institute for Comparative Genomics at AMNH.
 
The scientists will map information about the evolutionary importance of certain parts of genes and study how proteins are encoded into the genomes in order to find out what all the proteins are doing. The research will focus on using bioinformatics techniques and will be conducted using the World Community Grid, which is an IBM-supported computing platform that involves 400,000 volunteer computers worldwide.
 
NYU said that scientists at its Courant Institute of Mathematical Sciences, which is run by Bonneau, have already used the grid to develop structure predictions for more than 150 genomes.
 
These methods will be useful for annotating proteins that have unknown functions, and which currently have no detectable similarity to another protein with a known structure. Annotating these proteins means translating the gene sequence into predictions about how the gene functions, NYU said.
 
The project also will be linked to a continuing education program at NYU’s Steinhardt School for Culture, Education, and Human Development to train teachers how to use bioinformatics in high school science classes.

The Scan

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.

Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.

Multiple Myeloma Progression Influenced by Immune Microenvironment Expression

Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.