Thermo Fisher Scientific introduced this week a new data-independent acquisition capability for its Q Exactive mass spectrometer. In DIA, the mass spectrometer selects broad m/z windows and fragments all precursors in that window, allowing the machine to collect MS/MS spectra on all ions in a sample. This differs from data-dependent acquisition, in which the machine performs an initial scan of precursor ions and selects a sampling of those for fragmentation and generation of MS/MS spectra.

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