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New Products: Thermo Fisher, AB Sciex, Bruker, and More


Thermo Fisher Scientific introduced this week a new data-independent acquisition capability for its Q Exactive mass spectrometer. In DIA, the mass spectrometer selects broad m/z windows and fragments all precursors in that window, allowing the machine to collect MS/MS spectra on all ions in a sample. This differs from data-dependent acquisition, in which the machine performs an initial scan of precursor ions and selects a sampling of those for fragmentation and generation of MS/MS spectra.

The capability is available through a developer's kit for Q Exactive customers.

Thermo Fisher also introduced this week version 2.0 of its Proteome Discoverer software, and announced as part of the release that it has licensed Protein Metrics' Byonic database search software for improved analysis of post-translational modifications.

The new version of Proteome Discoverer combines spectral library searching with traditional database searching and includes a multi-threaded Sequest search engine that, the company said, takes advantage of new computer architectures to speed up database searches.

AB Sciex announced this week the release of its new Eksigent ekspert nanoLC 400 system, a plug-and-play LC system that integrates nanoLC and microLC on the same platform.

The new system allows researchers to easily move from nanoLC to higher flow microLC, making it a platform well-suited to qual-quan workflows enabled by mass spec instruments like AB Sciex's TripleTOF 5600, the company said.

Bruker announced this week that it has collaborated with the University of Washington on a version of Skyline software supporting its Maxis Q-TOF mass spectrometers.

The Skyline program, which is a widely used package for building and analyzing selected-reaction monitoring mass spec assays and data-independent acquisition workflows, will enable functions including MS1 filtering, targeted MS/MS, and DIA on Bruker instruments.

Bio-Rad this week introduced new Mini-Protean TGX Stain-free precast gels in gradient format.

Using the gels, researchers doing western blotting can perform protein separation, gel imaging, and data analysis in 20 minutes, the company said.

ProteinSimple this week introduced its new Peggy Simple Western, a fully automated western blot platform capable of performing up to 96 westerns in a single run.

Genedata this week released its new Expressionist MSX software for mid- to low-throughput proteomics and metabolomics research.

The software is a lower cost version of the company's high-end enterprise level Expressionist product and supports a variety of mass spec workflows including LC-MS/MS, SILAC, and MRM.

RayBiotech said it has achieved formal compliance in Good Manufacturing Practices and Good Laboratory Practices and has constructed a GLP-compliance laboratory out of which it will now offer ELISA and antibody array biomarker analysis services.

The Scan

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.

Algorithm Teases Out Genetic Ancestry in Individuals at Biobank Scale

Researchers develop an algorithm known as Rye to tease apart ancestry fractions in admixed individuals at a biobank-scale, applying it to 488,221 UK Biobank participants in Nucleic Acids Research.

Multi-Ancestry Analysis Highlights Comparable Common Variants at Complex Trait-Linked Loci

Researchers in Nature Genetics examine common variants implicated in more than three dozen conditions, estimating genetic effect similarities across ancestry tracts in admixed individuals.

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.