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New Products: Quest Diagnostics, Genalyte

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Quest Diagnostics this week released two tests for the diagnosis of rheumatoid arthritis based on the 14-3-3eta protein.

One test consists 14-3-3eta protein alone, while the other includes this protein along with established RA markers cyclic citrullinated peptide antibodies and rheumatoid factor. The tests, are intended for the diagnosis of RA, and early diagnosis of the disease in particular, the company said.

Quest licensed US rights to the 14-3-3eta protein from Canadian biotech firm Augurex (see related story this issue).


Genalyte this week released its MT-ADA anti-drug antibody immunogenicity assay for drug development.

The assay is intended for detecting unwanted immune responses to drugs by measuring the presence of anti-drug antibodies. The test allows for simultaneous detection of eight antibody classes and can be used for both mouse and human samples, the company said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.