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New Products at HUPO

Invitrogen announced this week at the Human Proteome Organization’s 6th Annual World Congress a new service enabling scientists to identify substrates of E3 ubiquitin ligases using its ProtoArray protein microarrays. The approach is based on research that used the ProtoArray to discover novel substrates for the E3 ligases on a global scale. The novel approach to screening global ubiquitination “enables both elucidation of E3-based cellular pathways as well as identification of potential drug targets,” Invitrogen said in a statement.
The company also said that it is making available to HUPO members for free the protein standard mixture that was used by the organization in its protein standard initiative.
HUPO members will be able to get the mixture for no cost until the end of the year. In early 2008, the mixture will become commercially available to all researchers.

Sigma-Aldrich launched a new protein standard mixture containing 48 human proteins with a dynamic range of 0.5 fmoles to 50 pmoles. The new mixture is built upon a mixture launched last year at HUPO in Long Beach and developed in collaboration with the Association of Biomolecular Resource Facilities [See PM 11/02/06].

PerkinElmer launched the Geliance 1000 2D imaging system, an update to the Geliance product line. The system has an optional advanced illumination unit that enables quick and accurate captures of images of multiplexed 2D gels for applications such as cellular, molecular, and cancer research. It captures images from fluorescent and visible stained gels and its design includes edge illumination “to excite proteins excited with cyanine dyes, producing high-quality images with superior accuracy and reliability,” the company said in a statement.
The company also released updates to four quantitative protein analysis products. The ExacTag S isobaric mass tag kit builds upon PerkinElmer’s ExacTag platform for protein expression quantification by mass spectrometry. According to the company, it is the only all-in-one protein quantitation reagent kit for enrichment and quantitation of low-abundance proteins in serum or plasma.
The ExacTag Analysis Software version 3.0 integrates the Mascot protein search engine. It automates communication with Mascot to enable one-step, unattended protein identification and quantitation.
Finally, its Phos-tag Gold and Phos-tag Enrich reagent kits build upon the company’s Phos-tag phosphoprotein gel and blot stains. Phos-tag Gold is a colorimetric assay for the identification and quantitation of phosphoproteins and phosphopeptides in solution. Phos-tag Enrich enriches phosphoproteins and phosphopeptides from biological samples.

Bruker Daltonics released the Compass 1.3 ion trap software, which contains a novel collision induced dissociation fragmentation mode called PAN. The new mode eliminates low mass cut-off of ion traps on MS/MS, and enables multiplexed quantitative proteome analyses, the company said in a statement.
The company also introduced the ProteinScape 2 software for LC-MS/MS protein analysis. The software supports all current label chemistries including multiplexed labels and label-free quantification. The ProteinScape 2 processing pipeline adopts the HUPO Brain Proteomics Project processing guidelines and
eventually will adopt the direct submission process of project data adhering to HUPO/PSI publishing guidelines.

Bio-Rad Laboratories pre-launched the ProteoMiner reagent kit for protein enrichment. The kit is based on a combinatorial library of hexapeptides. Unlike antibodies, the hexapeptides are not limited by sample type and “theoretically should be able to capture all protein types,” reducing the number of high-abundance proteins while magnifying the number of low-abundance ones, a company official told ProteoMonitor.
The kit will become commercially available within the next month and will sell for $650 in the US. Prices for other areas have not yet been determined. A kit will also be available for the company’s SELDI platform.

Geneva Bioinformatics launched a new version of the Phenyx protein identification and characterization platform. New features include an updated server-side code to accelerate searches and “more efficiently handle large DNA databanks,” the company said in a release. The new version also allows for full integration for the Institute of System Biology’s Trans Proteomics Pipeline and Proteome Software’s Scaffold.

And outside of HUPO, Kinaxo Biotechnologies said it has added quantitative analysis capability to its KinaTor chemical proteomics platform. The Kinator Cellular Profiling Service platform can be used in applications such as target identification, drug re-profiling, and drug rescue.

The Scan

Boosters Chasing Variants

The New York Times reports that an FDA advisory panel is to weigh updated booster vaccines for COVID-19.

Not Yet

The World Health Organization says monkeypox is not yet a global emergency, the Washington Post reports.

More Proposed for Federal Research

Science reports that US House of Representatives panels are seeking to increase federal research funding.

PLOS Papers on Breast Cancer Metastasis, Left-Sided Cardiac Defects, SARS-CoV-2 Monitoring

In PLOS this week: link between breast cancer metastasis and CLIC4, sequencing analysis of left-sided cardiac defects, and more.