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New Products at ASMS

Agilent introduced the newest version of its Multiple Affinity Removal System, the Human-14. The column removes 95 percent to 99 percent of the 14 most abundant proteins from human blood serum and plasma in one step, the company said in a statement. It is available in HPLC column or spin cartridge formats, and can be used for more than 200 runs.
The company also said that its MassHunter Workstation now has US Food and Drug Administration-compliance features. Customers can use the software to help them comply with 21 CFR Part II, an FDA regulation for how drug companies can author, approve, store, and distribute records electronically. The software also helps customers to meet current Good Manufacturing Practice requirements.
New features include security measures to ensure the integrity of data and results; a comprehensive audit trail for quantitative analysis; and customizable user roles and groups.
Additionally, Agilent introduced the High-Capacity Enrichment Column Chip and the Intact Protein Chip. Both are additions to the company’s 1200 Series HPLC-Chip/MS system. The High-Capacity Enrichment Column Chip helps separate low-abundance peptides from complex mixtures, while the Intact Protein Chip is for separating intact proteins.
And it released GeneSpring MS version 1.1 for biomarker discovery using mass spectrometry data. The system is compatible with data produced by the 6410 triple-quadrupole LC-MS system. It also supports data files in the exchange format mzXML.

Waters launched the MassPREP Phosphopeptide Enrichment Kit, enabling researchers to selectively enrich phosphopeptides for LC-MS analysis. The kit includes a 96-well micro-scale solid phase extraction plate packed with affinity sorbent. According to the company, the kit offers better performance than IMAC technology and achieves higher recovery of phosphopeptides than with other affinity-based methods.
It also rolled out the BiopharmaLynx software. It allows users to automatically characterize intact proteins and peptides by LC-MS, and automate data processing, analysis, and assignment of protein and peptide LC-MS data, the company said in a statement.

Bruker Daltonics launched the ImagePrep sample preparation device for automated matrix deposition on tissue slices. The device provides reproducible sample preparations for MALDI imaging in an automated, push-button process, the company said in a statement, and combines high-quality spectra with high image resolution of 50 microns.

Applied Biosystems launched MIDAS Workflow Designer version 1.1, a software package for automatically building multiple reaction monitoring methods. The product, said a company official, eliminates the tedious workflow from having to build them manually.
The company also introduced the MultiQuant software for quantitating proteins after MRM assays are run. The software can handle large numbers of MRM transitions and samples as well as labeling workflows.

PerkinElmer introduced a software upgrade for its ExacTag multiplexing platform for quantitative protein expression profiling by mass spectrometry. ExacTag Analysis Software version 2.0 uses signal intensity measurement from low mass reporter ions generated in the collision cell of an MS/MS and protein identification from standard databases. Version 2.0 offers the full spectrum of data resolution, the company said in a statement, and more data visualization and manipulation options “to hone in on cluster results, and render as visual heat maps.”

Protein Discovery launched the PPS Silent Surfactant Trial Program. The program is aimed at introducing to mass spectrometrists the benefits of using specialty surfactants to prepare samples for proteolytic digestion and mass spectrometry analysis.
The trial program remains active until Aug. 30 and is reserved for subscribers of the company’s “Sample Prep” newsletter. Participants will receive two vials of PPS for the price of one. The surfactant is delivered in 1 mg and 10 mg vials.

The Scan

Boosters Chasing Variants

The New York Times reports that an FDA advisory panel is to weigh updated booster vaccines for COVID-19.

Not Yet

The World Health Organization says monkeypox is not yet a global emergency, the Washington Post reports.

More Proposed for Federal Research

Science reports that US House of Representatives panels are seeking to increase federal research funding.

PLOS Papers on Breast Cancer Metastasis, Left-Sided Cardiac Defects, SARS-CoV-2 Monitoring

In PLOS this week: link between breast cancer metastasis and CLIC4, sequencing analysis of left-sided cardiac defects, and more.