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New Products: May 21, 2010

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Agilent Technologies announced this week that it will be introducing its new 6490 Triple Quadrupole LC/MS System at the American Society for Mass Spectrometry's annual meeting next week.

The system, which employs the company's new iFunnel technology, will offer a level of sensitivity 10 times higher than Agilent's 6460 Triple Quadrupole LC/MS System, the company said in a statement. The iFunnel technology represents a new approach to atmospheric pressure ion sampling, one that the company said will allow for the detection of molecules at the zeptomole level and for a linear dynamic range that extends to six orders of magnitude for many compounds.


Bruker this week announced the launch of its new Autoflex Speed MALDI-TOF (/TOF) mass spectrometer, which features a 1kHz smartbeam-II laser along with a 4 Gs/s digitizer and Bruker's PAN and FlashDetector technologies.

The system comes with a FAST-SRM mode for single reaction monitoring and incorporates Bruker's T3-Sequencing technology for long sequence readouts.

The Autoflex Speed will "enhance the productivity of laboratories involved in protein sequencing, biomarker discovery, polymer analysis, lipid and glycan analysis, molecular imaging, drug and metabolite tissue distribution, as well as high-throughput MALDI Biotyper microbiological molecular identification," the company said in a statement.

The Autoflex Speed is designed as an accessible and cost effective system to complement Bruker's higher-end ultrafleXtreme MALDI-TOF/TOF platform, the company said.


Biocius Life Sciences and Agilent Technologies this week launched the RF360 High Resolution System – a technology for high-throughput screening of in vitro ADME assays that integrates Biocius's RapidFire software with Agilent's TOF mass spectrometers.

The system allows researchers to perform a range of ADME assays – including drug-drug interaction, metabolic stability, Caco-2, and PAMPA – without having a priori knowledge of the test compound, Biocius and Agilent said in a joint statement. Instead, the companies said, this data can be extracted using RapidFire software after subjecting test compounds to a full TOF-MS scan, thereby eliminating time-intensive LC/MS assay development steps.


This week IonSense introduced its 3+D MicroPlate-96 Screening Plate, a new product designed to speed rapid sample screening in food safety, surface contamination, and pharmaceutical process development.

The new plate – designed for use with the DART (Direct Analysis in Real Time) 3+D Scanner – combines high-speed chemical analysis via DART MS with standard laboratory automation. It offers independent desorption ionization regions for each of the 96 wells on a standard microtiter plate and can function as a high-throughput screening system in rapid analysis mode or use longer exposure periods to provide more quantitative results, IonSense said in a statement.


NuSep this week releases its ProteoIQ 2.0 software, a bioinformatics tool for the analysis of proteomics data.

The software introduces a new metabolic labeling module that can be used with any isotope labeling strategy that alters the precursor mass, meaning that it now supports major proteomic quantification strategies like SILAC and ICAT. Additionally, the software's integrated statistical analysis of variance, assessments of reproducibility, and point-and-click normalization functions improve users' ability to identify changes in protein expression, the company said in a statement.


New England Peptide introduced this week NEPTune, a new series of proteomics reagents aimed at biomarker discovery and assay development.

The NEPTune line comprises four products – NEPTune Assay Discovery Peptides, NEPTune Assay Verification Peptides, NEPTune Assay Refinement Peptides, and NEPTune Clinical Assay Peptides. The products are designed to provide solutions for biomarker research ranging from the discovery phase through to clinical assay production, the company said in a statement.

The Scan

Renewed Gain-of-Function Worries

The New York Times writes that the pandemic is renewing concerns about gain-of-function research.

Who's Getting the Patents?

A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports.

Other Uses

CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SARS-CoV-2.

PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More

In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.