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New Products: Mar 26, 2010

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Eksigent introduced the ExpressLC-Ultra at Pittcon held earlier this month.

The microscale HPLC runs at column pressures up to 10,000 psi, allowing the use of sub-2 micron particle columns. The instrument has a new UV detection system, and delivers the advantages of microscale LC, such as solvent savings, reduced sample requirements, and reduced frictional heating, Eksigent said in a statement.

The system's CCD-based UV detector works with microfabricated flow cells "to ensure ultra-high sensitivity with no band broadening," Eksigent said. Its high sensitivity enables the detection of impurities at levels as low as 0.05 percent, the company added.


Protein Discovery this week launched a line of cartridge kits for its Gelfree 8100 fractionation system.

The kits allow researchers to perform molecular-weight fractionation with liquid phase recovery over various target mass ranges, the company said in a statement.

The Low Mass Cartridge Kit provides “maximum” separation resolution of proteins with molecular weight below 60 kDa. The Mid Mass Cartridge Kit is for separation of proteins between 3.5kDa and 150 kDa in mass, and the High Mass Cartridge Kit is designed for targeted enrichment of intact biotherapeutics, providing resolution in the mass range of 60 kDa and 300 kDa.


ChromoTek this week launched the RFP-Trap to identify and pull down interaction partners of proteins tagged with red fluorescent protein, and the GFP Booster, to increase the green fluorescent protein signal in super-resolution microscopy.

According to the German firm, RFP-Trap is used for biochemical and cell biological analysis of RFG-tagged fusion proteins in pull-down assays, a frequently used in vitro method for determining physical interaction between two or more proteins.

GFP Booster consists of a chemical fluorescent dye covalently attached to a GFP nanotrap, which provides high fluorescence intensities and signal-to-noise ratios, the company said.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.