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New Products: Mar 5, 2010

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Shimadzu launched the Nexera UHPLC system this week at Pittcon.

The system "is optimized to enable analysis at pressures up to 130 MPa," Shimadzu said in a statement, while an injection rate of about 10 seconds enables fast chromatography shortening cycle times, resulting in true high throughput with greater than 4,600 sample capacity.

Nexera has a newly designed injection port and fine-tipped needle. These along with other features, such as multiple-rinse solvent selection and injection port and internal needle rinse, reduce carryover to a minimum, the company said.


Also at Pittcon Wyatt Technology introduced its Möbiuζ mobility instrument for measuring macromolecular electrophoretic mobilities.

In addition to being able to measure the mobility of large particles such as liposomes and virus-like particles, the Möbiuζ is the only laser-based instrument that can reproducibly measure protein samples, such as antibody formulations, bovine serum albumin, and lysozyme, that have been traditionally "very challenging," Wyatt said in a statement.

The Möbiuζ is designed "specifically to address the unique measurement of protein mobilities" and is not "a remake of a device designed to measure particulates," the company added.

According to Wyatt, a "much shortened" measurement time and the availability of sufficient data "to average away molecular diffusion" is key to successfully measuring protein mobility. Its Möbiuζ achieves this through massive parallelism of detection "and extends the measurable molecular size range below 2 nm," Wyatt said. Meanwhile, a reduced measurement time, usually below 1 minute, helps preserve protein samples.

The Scan

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A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.