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A version 2.0 of the proteomics data repository Tranche will be launched in about a month, Phil Andrews, whose research team supports it, said this week at the meeting of National Cancer Institute-Clinical Proteomic Technologies for Cancer initiative

Andrews is a professor of biological chemistry at the University of Michigan, where he and his colleagues developed Tranche.

Among the changes to the updated version will be more storage capacity and will incorporate feedback from researchers, including those connected with CPTC. Andrews and his team also are building support for mzML, he said.

Currently, Tranche has 403 registered users and contains 8,259 datasets totaling more than 10.8 Tbytes of data. Since February nearly 8 Tbytes of data have been downloaded,Andrew said.


Researchers at the University of Washington have developed a free and open-sour computer program for building select-reaction monitoring and multiple-reaction monitoring methods and analyzing the experimental results.

The program is a Windows client called Skyline, and can output transition lists from Life Technologies' AB/Sciex, Agilent Technologies, Thermo Fisher Scientific, and Waters triple-quadrupole mass spectrometers, Michael MacCoss, an associate professor in genome sciences at the university, said in an announcement.

The program can also visualize and process the data from native raw instrument files from the same instruments, and make use of peptide MS/MS spectrum libraries in BiblioSpec, TheGPM, and NIST formats. It can automatically build spectrum libraries from a number of common database search engines, MacCoss added.

Information about the program and obtaining and installing it can be found here.

Software developers can find the source code in the ProteoWizard Project here.


Arrayit said this week it has launched a next-generation proteomics platform.

The platform "provides a patented and comprehensive instrumentation, software, and consumables solution for peptide microarray analysis," according to Arrayit, a microarray developer based in Sunnyvale, Calif.

The Scan

Highly Similar

Researchers have uncovered bat viruses that are highly similar to SARS-CoV-2, according to Nature News.

Gain of Oversight

According to the Wall Street Journal, the Biden Administration is considering greater oversight of gain-of-function research.

Lasker for mRNA Vaccine Work

The Scientist reports that researchers whose work enabled the development of mRNA-based vaccines are among this year's Lasker Award winners

PLOS Papers on Causal Variant Mapping, Ancient Salmonella, ALK Fusion Test for NSCLC

In PLOS this week: MsCAVIAR approach to map causal variants, analysis of ancient Salmonella, and more.