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New Products: Jun 4, 2009

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At ASMS this week:

Thermo Fisher Scientific launched Intelligent Selected Reaction Monitoring, which improves the throughput of SRM assays.

ISRM, available on all Thermo Fisher TSQ instruments, increases the sensitivity and selectivity of targeted quantitation assays for verifying and quantifying targeted proteins simultaneously.

The company also released Pinpoint software for the automated method development and quantitative analysis of SRM-based targeted peptide assays. Pinpoint is available as a free download here.


Waters launched eight MassLynx workflow enhancements this week. They are the Posi±ive system for high-throughput screening of complex food safety, water quality, and environmental samples; BiopharmaLynx 1.2 for peptide characterization; ProteinLynx Global Server 2.4 to manage large proteomic datasets on the nanoAcquity 2D UPLC/MSE; Quanpedia, QCMonitor, and Trendplot quantitative software for a broad range of Waters mass specs; OpenLynx Open Access for laboratories to increase their productivity; HL7 LIMS integration; MetaboLynx XS and MarkerLynx XS for metabolite identification and profiling; and Driftscope 2.1 featuring ion mobility peak detection, visualization and comparison, and collision cross section determinations.


Shimadzu introduced the PTM Finder software for the identification of post-translational modifications in complex protein samples.

The software allows for the identification of peptide sequences carrying one or more modifications using MS/MS data and facilitates consecutive Mascot searches "using all the functionality of the MS/MS ion search," the company said in a statement. It is designed for easy import of amino acid sequences using a simple copy/paste function or of the proteins derived from the initial Mascot search results.

Shimadzu also launched the SeqLab de novo sequencing software. It uses a "high powered" de novo sequencing engine and allows the use of MS/MS data and MS/MS/MS data that may be related to help decipher peptide sequences.


GeneData launched Expressionist 5.2 for mass-spec based biomarker discovery.

The software includes advanced Refiner MS and Analyst modules which process and analyze metabolomic and proteomic raw danta and provide "sophisticated statistical analysi capabilities for large volume data sets," the company said in a statement.

In addition to supporting ABI Wiff files, version 5.2 of Refiner MS supports Thermo Fisher Scientific's Exactive and GC-MS platforms and Agilent's Q-TOF and GC-MS instruments. Peak identification and annotation tools in Expressionist have been advanced to offer links to search engines and databases, including Mascot and HMDB, GeneData said. Improved library searches are also possible via computation of retention-time indices.

Away from ASMS:

Pressure Biosciences last week launched the PCT MicroTuber Adapter Kit for use with the company's PCT Sample Preparation System.

The kit includes an ergonomically designed, space-saving workstation, PCT MicroTubes and MicroCaps, and tools that allow researchers to process up to 48 samples simultaneously in the PCT Sample Preparation System, compared to three currently.


The National Institute of Standards and Technology this week launched its latest peptide mass spectral libraries available here and here.

The institute also introduced the NIST MSPepSearch search engine for searching peptide mass spectral libraries.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.