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New Products: May 28, 2009


GE Healthcare this week launched the ÄKTAmicro liquid chromatography system, which it said is designed specifically for small sample volumes and concentrations.

The system in completely bioinert and can be used for the purification of target molecules from a range of sources, including proteins and protein complexes, GE Healthcare said in a statement.

The system includes a Microfraction Collection Kit for collection of minute fraction volumes and an adapted Unicorn software wizard system for ease of use.

Protein Discovery said it will be launching the Gelfree 8100 Fractionation System at the annual conference of the American Society for Mass Spectrometry starting May 31.

According to the Knoxville, Tenn.-based firm, Gelfree 8100 is the first instrument for proteomics that partitions complex protein mixtures into user-selectable, liquid-phase molecular weight fractions.

According to Jeremy Norris, vice president of R&D for Protein Discovery, the system gives high and reproducible recoveries of any fraction from 3.5 kiloDaltons to 150 kiloDaltons, "and you can load each cartridge with up to 8 milligrams of sample so you can study very low-abundance proteins," he said in a statement.

It added that it expects the new system to be used broadly by proteomics research laboratories in conjunction with routine research techniques such as IEF, trypsin digestion, Western blotting, and LC-MS.

BioTrove this week launched its RapidFire 300 MS platform for in vitro ADME assays.

The new platform builds on the RapidFire 200 and expands the in vitro ADME applications of the instrument beyond drug-drug interactions, the company said in a statement, to research into P-glycoprotein inbibition, plasma protein binding, and other areas.

The RapidFire 300 produces label-free data at six to eight seconds per sample.

ForteBio launched two assay modules for use on the company's Octet instrument platform.

One module is for high-sensitivity protein quantitation, and the other is for fragment screening.

The modules are available via software upgrades and "will enable, for the first time, life science researchers who require those capabilities to access the high-throughput, ease-of-use, and cost-effectiveness," of the Menlo Park, Calif.-based firm's label-free technology, it said in a statement.

The new high-sensitivity assay module detects low nanogram per milliliter levels of analytes in quantitation mode. The fragment screening assay module extends ForteBio's small-molecule analysis capabilities by enabling kinetic characterization and the screening of fragment libraries, including compounds in the 150 Dalton to 300 Dalton range.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.