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New Products: Jun 10, 2011


A number of vendors introduced new proteomics products at the American Society for Mass Spectrometry meeting in Denver this week. The following is a roundup of new offerings introduced at the conference.

Agilent introduced its new 6550 iFunnel Q-TOF as well as its 6420 triple quadrupole.

The new Q-TOF features 50 Hz acquisition rates, up to five orders of intra-scan dynamic range, and 10 times the sensitivity of its previous Q-TOF models, the company said.

The 6420 is an upgradable system, designed as a replacement for the company's 6410 triple quad that can be upgraded to the higher-performance 6430 and 6460 instruments to accommodate changing lab needs.

Waters released its new Synapt G2-S mass spectrometer and its Xevo TQD tandem quadrupole instrument.

The G2-S incorporates the company's Triwave ion mobility technology and its StepWave ion transfer optics, providing a 30-fold jump in signal intensity for mass spectral peaks, a five-fold improvement in signal-to-noise ratio, and a 10-fold leap in limits of quantitation compared to the original Synapt, Waters said.

The Xevo TQD features Waters' RADAR technology, which the company said collects data in both MRM and full scan mode simultaneously, allowing researchers to monitor for matrix interferences, metabolites, impurities, and degradants in their samples while quantifying target compounds.

Bruker introduced its CaptiveSpray electrospray ion source for nano-HPLC applications in proteomics.

The CaptiveSpray source fits all Bruker LC-MS instruments. According to the company it simplifies nanospray use via a plug-and-play design and enables increased LC flow rates, allowing for reduced column loading times, increased sample loading capacity, and expanded dynamic range.

Thermo Fisher Scientific introduced a series of reagents and systems for proteomics research, including: the Thermo Scientific Pierce Kinase Enrichment Kit, the Thermo Scientific Pierce GTPase Enrichment Kit, and the Thermo Scientific ActivX Serine Hydrolase Probes for the capture and identification of a variety of peptide and protein classes.

The company also released the Thermo Scientific Pierce Peptide Calibration Mixture and Thermo Scientific Pierce PEPotec SRM peptide library for developing SRM assays, as well as the Thermo Scientific EASY-nLC 1000 – a split-free nano-flow LC system for protein and peptide research.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.