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New High-End Mass Specs by Shimadzu, Waters On the Menu For Upcoming ASMS Conference


Shimadzu, Waters, and other proteomic tool vendors will showcase new high-end mass spectrometers during the American Society for Mass Spectrometry conference, to be held on May 28 — June 1 in Seattle.

For Shimadzu, its new AXIMA-TOF2 has an improved curved field reflectron technology, which is used to deliver high-energy collision-induced dissociation (CID) data without the need for post-acceleration, said Emmanuel Raptakis, product manager for MALDI-TOF instruments at Shimadzu.

The improved CFR technology "translates to higher sensitivity," said Raptakis. "We extract the [ion] beam completely, and the energy is maintained throughout the time-of-flight ion path. We make sure you don't lose any ions on the ion path. The higher transmission leads to higher real-time sensitivity."

CFR technology was originated by Shimadzu's wholly owned subsidiary Kratos Analytical about eight years ago, said Raptakis. Shimadzu's predecessor AXIMA-CFR and MALDI AXIMA CFR Plus instruments also use CFR technology, but with the new AXIMA-TOF2, the shape of the field has been improved so that quality is improved in the low-mass ion range, he said.

"This definitely outperforms the CFR Plus in terms of the results it can provide," said Raptakis. "It delivers really high energy CID, which gives you more information for proteomic samples."

In terms of throughput, Raptakis said the AXIMA-TOF2 is fast enough for researchers who want to analyze up to a few hundred samples per day, but "is not designed for ultra-high throughput."

Beta testers of the AXIMA-TOF2 include research groups at the University of Vienna, the Technical University of Vienna, a group in Heidelberg, Germany, and several groups in Japan, Raptakis said.

Raptakis declined to give a price for the new AXIMA-TOF2, but said that it is more expensive than the AXIMA CFR Plus. The instrument is currently available for order.


In a statement, Waters said the new version of its LCT Premier time-of-flight bench-top mass spectrometer, called the LCT Premier XE, includes the company's patented LockSpray technology for exact mass measurement, and a new wizard-driven instrument setup protocol.

The original version of the LCT Premier was launched during the 2003 ASMS conference in Montreal (see ProteoMonitor 6/6/2003). It is designed for routine applications in natural product identification, drug metabolism, impurity analysis, compound screening, and intact protein analysis.

According to Waters' website, the new LCT Premier XE offers an enhanced resolution of 15,000 FWHM over 30,000 m/z. The instrument offers a rapid spectral acquisition rate and wide dynamic range, making it "ideal" for qualitative applications, Waters said.

Other Vendors

Other major mass spec players, including Thermo Electron, Bruker, Applied Biosystems, and Agilent preferred to keep their new products under wraps until they make their debut at the ASMS conference.

Agilent officials said they would talk about the "major roadblocks in proteomics research" during their press conference at ASMS, and present ways that they have tried to address those roadblocks through separation technologies, sensitive mass specs — such as the 6510 Q-TOF — and proteomics software, including the MassHunter Workstation, Spectrum Mill, and GeneSpring MS.

Knoxville, Tenn.-based Protein Discovery will make their inaugural appearance at this year's ASMS. They will preview their MALDIplex M5 Sample Prep Station — a new system for preparing 96 MALDI-ready protein samples from serum in less than one hour. In addition, they will showcase their new robotic MALDI matrix sprayer, which was developed in partnership with LEAP Technologies (see ProteoMonitor 4/20/2006), and their new PPS Silent Surfactant, an acid-cleavable detergent for cell membrane disruption and protein solubilization (see ProteoMonitor 5/11/2006).

Other proteomics products to be showcased at ASMS include Sigma-Aldrich's ProteoPrep 20 Kit, launched in January, which removes 99 percent of 20 high-abundant plasma proteins (see ProteoMonitor 2/2/2006), and new systems biology-focused products by bioinformatics company GenoLogics.

— Tien-Shun Lee ([email protected])

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