Skip to main content
Premium Trial:

Request an Annual Quote

NCI Releases Breast Cancer Proteomic Data from CPTAC

NEW YORK (GenomeWeb News) – The National Cancer Institute today said that it has released a dataset of proteins and phosphopeptides identified by researchers using deep proteomic and phosphoproteomic methods to analyze breast cancer samples.

The dataset was generated by NCI's Clinical Proteomic Tumor Analysis Consortium, which included researchers from the Broad Institute, Fred Hutchinson Cancer Research Center, and Washington University of St. Louis. The investigators used iTRAQ protein quantification methods to develop the dataset of from 105 breast cancer samples.

The CPTAC researchers analyzed samples that had been previously genomically analyzed by the The Cancer Genome Atlas project. According to NCI, it is "largest-ever public dataset of proteins designed to complement deep genomic sequencing data on the same tumor."

"This dataset provides researchers the opportunity to develop and test novel proteogenomic integration tools and algorithms to extend our knowledge of the biological underpinnings of cancer," NCI said in a statement.

The dataset can be accessed through the CPTAC Data Portal.

The Scan

Foxtail Millet Pangenome, Graph-Based Reference Genome

Researchers in Nature Genetics described their generation of a foxtail millet pangenome, which they say can help in crop trait improvement.

Protein Length Distribution Consistent Across Species

An analysis in Genome Biology compares the lengths of proteins across more than 2,300 species, finding similar length distributions.

Novel Genetic Loci Linked to Insulin Resistance in New Study

A team reports in Nature Genetics that it used glucose challenge test data to home in on candidate genes involved in GLUT4 expression or trafficking.

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.