Skip to main content
Premium Trial:

Request an Annual Quote

NCCN Including Use of VeriStrat in NSCLC Guidelines

NEW YORK (GenomeWeb) – The National Comprehensive Cancer Network has approved inclusion of Biodesix's VeriStrat proteomics test in its guidelines for non-small cell lung cancer, the Boulder, Colo.-based firm said today.

The updated guidelines recommend use of the test to help determine whether NSCLC patients entering the second line of treatment should receive Genentech's Tarceva (erlotinib), a targeted therapy which has fewer side effects and offers greater convenience compared to other standard chemotherapies. The NCCN guideline recommends VeriStrat for NSCLC patients with wild-type EGFR or with unknown EGFR status.

Biodesix noted that the guidelines state that "a patient with 'poor' classification should not be offered erlotinib in the second-line setting."

While erlotinib is often used in NSCLC patients with an EFGR mutation, such a mutation is seen in only a small percentage of patients, Biodesix said. VeriStrat helps clinicians identify those who may benefit from a targeted therapy.

"The goal, from a diagnostic perspective, is to identify patients who differentially respond to available therapies in this devastating disease," Biodesix CMO Richard Hockett said in a statement. "The ability of VeriStrat to provide prognostic and therapeutic guidance to improve patient outcomes is gaining wider recognition as standard of care by inclusion in NCCN guidelines."

The NCCN's decision follows last month's decision by Blue Cross Blue Shield affiliate Highmark to cover VeriStrat.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.