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National Institute of General Medical Sciences’ Protein Structure Initiative, Advion, Millipore, Protea

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The National Institute of General Medical Sciences’ Protein Structure Initiative this week launched the PSI Structural Genomics Knowledgebase, available here, an entry point to all the protein structure and production resources created by the PSI.
 
Researchers can enter the sequence of a protein into a search box on the home page to find the corresponding structure and ones similar to it, as well as information about their functions and reports on how the structures were generated. There is also a glossary of terms and acronyms.
 
The site also serves as a gateway to other information, including descriptions of new technologies and methods, a list of publications on new findings, and funding opportunities.
 
To date, PSI centers have generated 2,800 protein structures and developed techniques that “significantly improve the steps of structure determination,” according to the National Institutes of Health.
 

 
Advion this week launched the RePlay and FloTek systems.
 
RePlay is a nanoLC tool that splits a chromatographic run into two separations,directing one to the mass spectrometer for analysis and the other to the capture cartridge. After the initial MS analysis, RePlay switches flow and the captured chromatographic separation is analyzed while the nanoLC system reequilibrates “thereby increasing mass spectrometer utilization time while decreasing the need for extra time and sample,” Advion said in a statement.
 
RePlay is suited for protein identification and structural identification of post-translational modifications, and is suitable for all nanosprayers. It is also compatible with existing nanoLC systems and mass spectrometers.
 
FloTek, a digital nanoflow meter allows nanoLC users to determine flow rates from their existing nanoLC systems. It is intended to monitor nanoLC performance and assist in diagnosing nanoLC system issues.
 

 
Millipore this week launched the SNAP i.d. protein detection system, which allows researchers to produce “higher-quality” Western blots 80 percent more quickly than with conventional immunodetection protocols, according to the company.
 
SNAP shortens the time required for blocking, washing, and antibody incubations to 30 minutes, Millipore said. The system is compatible with all membrane types and detection methods and sensitivity and specificity are equivalent or higher than standard immunodetection.
 

 
Protea this week introduced the LithTips family of protein preparation products. The products use proprietary monolithic chromatographic chemistry “that is highly porous, resulting in higher flow rates and increased resistance to clossign, as well as greater surface area, proving better sample loading capacities,” the company said in a statement.
 
LithTips are available as C4, C8, and C18 reversed-phase chemistries.