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National Center for Genome Resources, Waters, Aclara BioSciences, Amersham Biosciences


The National Center for Genome Resources has released PathDB version 2.0, a research tool for scientists interested in analyzing their experimental or computational data in the context of biological pathways and networks. The software is both a data repository and a system for building and visualizing cellular networks. Uses include finding all pathways and phenotypes associated with genes in a cluster or validating computationally predicted associations with known biological data. Version 2.0 includes improvements in data modeling and data acquisition. The data model has changed from a concrete model of metabolism, primarily supporting curation from literature, to an abstract model for all kinds of cellular function, e.g. signal cascade, gene regulatory, protein-protein interaction, and protein-small molecule binding data, as well as metabolism. The client download is available from NCGR’s web site at PathDB 2.0 is free for non-commercial users; commercial users can evaluate the client download model for free.

Waters has introduced MassLynx 4.0, a security manager product for its Mass-Informatics platform. It facilitates secure quantitative analysis in 21 CFR 11-compliant laboratories, allowing researchers to configure over 70 access privileges for individual and grouped users. Furthermore, Waters has introduced the latest version of QuanOptimise, a plug-in for Mass-Informatics that allows multi-compound quantification studies through a graphical user interface.

Aclara BioSciences has launched its eTag assay system for studying multiplexed gene and protein expression. Specific molecular binding events that occur during a reaction result in the release of electrophoretically distinct eTag reporters, which are then resolved, allowing quantitation of multiple analytes directly from cell lysates. For high-throughput multiplexed protein analysis of secreted proteins or cell-surface antigens, Aclara has developed eTag multiplex protein proximity assay methods. The eTag assay system will be commercialized under a license-based access program that includes gene expression profiling, protein expression analysis, and cell-surface antigen assays. The program includes eTag reagent kits and software, custom assay services, and consulting support.

Amersham Biosciences has released a CD-ROM version of “Protein Purifier,” a protein purification teaching program. Users can choose from a variety of chromatographic techniques to design purification protocols for 20 different protein samples.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.