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National Center for Genome Resources, Waters, Aclara BioSciences, Amersham Biosciences


The National Center for Genome Resources has released PathDB version 2.0, a research tool for scientists interested in analyzing their experimental or computational data in the context of biological pathways and networks. The software is both a data repository and a system for building and visualizing cellular networks. Uses include finding all pathways and phenotypes associated with genes in a cluster or validating computationally predicted associations with known biological data. Version 2.0 includes improvements in data modeling and data acquisition. The data model has changed from a concrete model of metabolism, primarily supporting curation from literature, to an abstract model for all kinds of cellular function, e.g. signal cascade, gene regulatory, protein-protein interaction, and protein-small molecule binding data, as well as metabolism. The client download is available from NCGR’s web site at PathDB 2.0 is free for non-commercial users; commercial users can evaluate the client download model for free.

Waters has introduced MassLynx 4.0, a security manager product for its Mass-Informatics platform. It facilitates secure quantitative analysis in 21 CFR 11-compliant laboratories, allowing researchers to configure over 70 access privileges for individual and grouped users. Furthermore, Waters has introduced the latest version of QuanOptimise, a plug-in for Mass-Informatics that allows multi-compound quantification studies through a graphical user interface.

Aclara BioSciences has launched its eTag assay system for studying multiplexed gene and protein expression. Specific molecular binding events that occur during a reaction result in the release of electrophoretically distinct eTag reporters, which are then resolved, allowing quantitation of multiple analytes directly from cell lysates. For high-throughput multiplexed protein analysis of secreted proteins or cell-surface antigens, Aclara has developed eTag multiplex protein proximity assay methods. The eTag assay system will be commercialized under a license-based access program that includes gene expression profiling, protein expression analysis, and cell-surface antigen assays. The program includes eTag reagent kits and software, custom assay services, and consulting support.

Amersham Biosciences has released a CD-ROM version of “Protein Purifier,” a protein purification teaching program. Users can choose from a variety of chromatographic techniques to design purification protocols for 20 different protein samples.

The Scan

Rise of BA.5

The New York Times reports that the Omicron subvariant BA.5 has become the dominant version of SARS-CoV-2 in the US.

UK Health Secretary Resigns

Sajid Javid, the UK health secretary, resigned along with Chancellor Rishi Sunak, saying they cannot work with Prime Minister Boris Johnson's government, CNN reports.

Clones From Freeze-Dried Cells

A team in Japan has cloned mice from freeze-dried skin cells, according to the Guardian.

Genome Research Papers on Craniosynostosis, Macaque Retrotransposition, More

In Genome Research this week: structural variants in craniosynostosis, LINE-1 activity in rhesus macaque brain, and more.