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Molecular Devices, Drug & Market Development Publications, GE Healthcare

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Molecular Devices said last week that it has introduced the Transil Membrane Affinity and Transil Human Serum Albumin Binding assay kits. According to MD, the Transil Membrane Affinity assay uses beads that are coated with a lipid bilayer that mimic interactions between compounds and cell membranes. The Transil HSA Binding assay contains beads that have been coated with human serum albumin and pre-dispensed into a microplate format, which increases throughput on the company's SpectraMax microplate readers. Both kits are available in 96- or 384-well microplate formats, MD said.


Drug & Market Development Publications has released a new report entitled Proteases as Drug Targets: Technologies and Opportunities for Drug Discovery. According to D&MD, the report reviews the global protease market, discussing strategies to design peptidomimetic and non-peptidomimetic competitive inhibitors, as well as other types of inhibitors. The report also describes the main disease areas where proteases or their inhibitors are involved, including infectious diseases, inflammation and wounds, cancer, cardiovascular conditions and neurodegenerative diseases. Key companies active in the protease drug discovery area are profiled in the report.


GE Healthcare announced this week the launch of AKTAcrossflow, a fully automated, small-scale protein purification system designed to simplify cross flow membrane selection and process development. The system package includes hardware, software and membrane devices, GE said. It can be applied to sample volumes from 25 milliliters up to liter volumes.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.