Merck Uses Phosphoproteomics to Identify Potential Biomarkers for Cancer Drug Development | GenomeWeb

By Adam Bonislawski

A research team led by Merck scientists has taken what could represent a first step toward using phosphoproteins as biomarkers for cancer drug development.

Examining prostate cancer cells treated with three investigational drugs targeting the phosphatidylinositol 3-kinase, or PI3K, signaling pathway, the researchers identified 375 nonredundant serine-threonine phosphopeptides within the pathway, of which 71 were regulated by at least one drug and 11 were regulated by all three drugs.

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