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Like most large pharmaceutical companies, Merck invested heavily in gene expression profiling before paying much notice to proteomics. In fact, Merck’s proteomics group may have an even bigger chip on its shoulder: With the company’s acquisition of Rosetta Inpharmatics in May 2001, “there’s definitely a bias toward gene expression,” said Patrick Griffin, senior director of proteomics for Merck in Rahway, NJ.

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