Skip to main content
Premium Trial:

Request an Annual Quote

Large Scale Biology Corporation, University of California


The US Patent and Trademark Office has awarded another patent to Large Scale Biology Corporation for its automated 2D gel analysis system. US Patent No. 6,451,189 covers an automated computer-controlled method for imaging an electrophoresis gel to select specific spots for excision, storing spot position and abundance data in a database, and comparing the data with a database of 2D gel images to identify the proteins.

The University of California has been awarded US Patent No. 6,448,087 for a method that uses a solubility reporter to measure a protein’s solubility in vivo or in vitro. The reporter can be used in a single living cell to generate a signal indicating whether the protein of interest in the sample is soluble. The method includes the use of random mutagenesis methods to generate mutants of a protein, and the use of the reporter to screen for more soluble versions of the protein. Mutated variants can also be recombined to yield variants with further-enhanced solubility. The inventor, Geoffrey Waldo, is a researcher at the Los Alamos National Laboratory, which is operated by the University of California.

The Scan

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.

Study Presents New Insights Into How Cancer Cells Overcome Telomere Shortening

Researchers report in Nucleic Acids Research that ATRX-deficient cancer cells have increased activity of the alternative lengthening of telomeres pathway.

Researchers Link Telomere Length With Alzheimer's Disease

Within UK Biobank participants, longer leukocyte telomere length is associated with a reduced risk of dementia, according to a new study in PLOS One.

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.