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Johns Hopkins, Aclara, Tokyo Metropolitan Institute of Medical Science, Cell Signaling, Dana-Farber, Phosphoproteomics, NIDA, SurroMed, Stanford, NIAID, BU, UTMB

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Human protein reference database introduced

A team of scientists led by Akhilesh Pandey, assistant professor at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins, this week introduced the online Human Protein Reference Database in the October issue of Genome Research.
The database contains entries on the 3,000 most-studied human proteins, with information detailing interactions among the included proteins. Scientists hope to increase the number of entries to 10,000 by the end of the year. The database has already been active for five months, but was not formally introduced until now.


Aclara licenses eTag to Tokyo institute

Aclara BioSciences announced this week that is has made a deal with the Tokyo Metropolitan Institute of Medical Science to provide access to its eTag multiplexed assay system for the high throughput assaying of hypoxia-inducible factors in cells and tissues. The agreement includes providing TMIMS with access to eTag assays, reagent products, software, and support. TMIMS is allowed to use the eTag system only for certain genomics and proteomics applications.


Cell Signaling agrees to pay Dana-Farber Cancer Institute, Phosphoproteomics for antibody technology

Beverly, Mass.-based Cell Signaling Technology announced this week that it had agreed to make “certain cash payments” to the Dana-Farber Cancer Institute of Boston, Mass. and Phosphoproteomics of Guilford, Conn. in exchange for “freedom-to-operate” in research and diagnostic. Cell Signaling had been involved in a legal dispute with Dana-Farber and Phosphoproteomics over a phosphor-peptide specific antibody technology protected by patents that Dana-Farber and Phosphoproteomics held. The terms of the agreement were not disclosed.


NIDA dishes out $7.6M in stress and drug use grants

The National Institute on Drug Abuse announced this week that it had awarded 10 grants totaling $7.6 million over five years to study the relationship among chronic stress, repeated stressors, and brain mechanisms that affect drug use. Of these grants, one — awarded to Kathryn Cunningham at the University of Texas Medical Branch and totaling $363,000 over three years — will address “Targeted Proteomics of Stress and Addiction,” according to a statement released by the NIDA.


Surromed publishes new biomarker approach in Analytical Chem

Surromed announced this week the publication of its new LC-MS approach to biomarker discovery in Analytical Chemistry. The study, entitled “Quantification of Proteins and Metabolites by Mass Spectrometry Without Isotopic Labeling or Spiked Standards,” described the company’s method of quantifying differential expression of proteins.


Stanford to establish $700,000 biotech center for kids' diseases; will focus on genetics, genomics & proteomics

Stanford University School of Medicine announced this week that the Lucile Packard Children’s Hospital had given the school $700,000 to establish a center for biotechnology research focused on children’s health. The center will use genetics, genomics, and proteomics strategies to create diagnostics and prognostics for diseases particular to children.
The gift is the first investment of its kind that the hospital has made in the medical school, according to Packard. The biotechnology effort has already begun to focus on the following diseases: acute myelogenous leukemia, Kawasaki disease, diabetes, and necrotizing enterocolitis.


NIAID funds NBLS at BU and UTMB
The National Institute of Allergy and Infectious Diseases announced this week the awarding of $120 million each to Boston University and the University of Texas Medical Branch to build National Biocontainment Laboratories that will supplement the eight Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases funded three weeks ago (see PM 8-1-03, 9-12-03). The grants provide for the construction of biosafety level 2, 3, and 4 laboratories for use in biodefense research and reaction at the two sites.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.